Tyr1000
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Phosphorylation Site Page:
Tyr1000 - INSR (rat)

Site Information
YASSNPEyLSASDVF   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: INSR (mouse): Y989, INSR (human): Y999, INSR iso2 (human): Y987
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447685

In vivo Characterization
Methods used to characterize site in vivo: phospho-antibody (1, 2, 3), western blotting (1, 2, 3)
Relevant cell line - cell type - tissue: adipocyte-adipose tissue (3), liver (1, 2)

Controlled by
Treatments: hemorrhage (2), insulin (1, 2, 3), irbesartan (1), trauma (2), wortmannin (3)



References

1

Muñoz MC, et al. (2009) TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. J Endocrinol 201, 185-97
19251743   Curated Info

2

Ma Y, et al. (2004) Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha. Endocrinology 145, 5168-76
15297437   Curated Info

3

Hers I, et al. (2002) Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. Biochem J 368, 875-84
12220227   Curated Info

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