Ser34
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Phosphorylation Site Page:
Ser34 - RhoGDI alpha (rat)

Site Information
YKPPAQKsIQEIQEL   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: RhoGDI alpha (human): S34, RhoGDI alpha (mouse): S34, RHOGDI alpha iso3 (human): (S34)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467490

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1), mutation of modification site (3), phospho-antibody (2, 3), western blotting (2, 3)
Disease tissue studied: adrenal cancer (3), pheochromocytoma (3)
Relevant cell line - cell type - tissue: 'brain, brainstem' (1), 'brain, cerebellum' (1), 'brain, cerebral cortex' (1), adipose tissue (1), fibroblast-embryo (2), intestine (1), kidney (1), liver (1), lung (1), muscle (1), pancreas (1), PC-12 (chromaffin) (3), spleen (1), stomach (1), testis (1), thymus (1)

Controlled by
Putative upstream kinases: PAK2 (human) (3)
Kinases, in vitro: PAK2 (human) (3)
Treatments: U73122 (2)

Downstream Regulation
Effects of modification on RhoGDI alpha: molecular association, regulation (3)
Effects of modification on biological processes: cell growth, altered (3)
Inhibit interaction with: CDC42 iso1 (human) (3), RAC1 (rat) (3)


References

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

Dovas A, et al. (2010) Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. J Biol Chem 285, 23296-308
20472934   Curated Info

3

Shin EY, et al. (2009) Phosphorylation of RhoGDI1 by p21-activated kinase 2 mediates basic fibroblast growth factor-stimulated neurite outgrowth in PC12 cells. Biochem Biophys Res Commun 379, 384-9
19103160   Curated Info

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