Ser481
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Phosphorylation Site Page:
Ser481 - CTTNBP2NL (human)

Site Information
QQASGLQsPPsRDLs   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CTTNBP2NL (mouse): S481, CTTNBP2NL (rat): (S481)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449284

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
Disease tissue studied: breast cancer (3, 4), breast cancer, triple negative (3), cervical cancer (12), cervical adenocarcinoma (12), lung cancer (6, 7), non-small cell lung cancer (6), non-small cell lung adenocarcinoma (7), melanoma skin cancer (1)
Relevant cell line - cell type - tissue: 'stem, embryonic' (13), 293 (epithelial) (10, 14), A498 (renal) (11), breast (3), Calu 6 (pulmonary) (6), H1395 (pulmonary) (6), H2009 (pulmonary) (6), H2077 (pulmonary) (6), H2887 (pulmonary) (6), H322M (pulmonary) (6), HCC1359 (pulmonary) (6), HCC366 (pulmonary) (6), HCC4006 (pulmonary) (6), HCC78 (pulmonary) (6), HeLa (cervical) (2, 5, 8, 9, 15, 16, 17), HeLa S3 (cervical) (12), HMLER ('stem, breast cancer') (4), HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] (4), K562 (erythroid) (5), NCI-H1648 (pulmonary) (6), NCI-H2030 (pulmonary) (6), U-1810 (pulmonary) (7), U-1810 (pulmonary) [EFNB3 (human), knockdown] (7), WM239A (epidermal) (1)

Controlled by
Treatments: nocodazole (12)



References

1

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

5

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

6

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

7

Ståhl S, et al. (2011) Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor. J Proteome Res 10, 2566-78
21413766   Curated Info

8

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

9

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

10

Guo A (2010) CST Curation Set: 9975; Year: 2010; Biosample/Treatment: cell line, 293/mTOR inhibitor; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P Antibodies Used to Purify Peptides prior to LCMS: Millipore 05-368
Curated Info

11

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

12

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

13

Brill LM, et al. (2009) Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell 5, 204-13
19664994   Curated Info

14

Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501
19413330   Curated Info

15

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

16

Beausoleil SA, et al. (2006) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol 24, 1285-92
16964243   Curated Info

17

Beausoleil SA, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101, 12130-5
15302935   Curated Info

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