Thr492
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Phosphorylation Site Page:
Thr492 - Tau (rat)

Site Information
KTTPSPKtPPGSGEP   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: Tau (human): T498, Tau (mouse): T473, Tau iso8 (human): T181, Tau iso5 (human): T181, Tau iso7 (mouse): T112, Tau iso6 (human): T123, Tau iso7 (human): (T152), Tau iso3 (mouse): (T170), Tau (cow): (T172), Tau iso2 (human): (T123), Tau iso3 (human): (T87)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447932

In vivo Characterization
Methods used to characterize site in vivo: amino acid analysis (6), mass spectrometry (2, 3, 4), peptide sequencing (6), phospho-antibody (5), phosphoamino acid analysis (6)
Disease tissue studied: Alzheimer's disease (5)
Relevant cell line - cell type - tissue: 'brain, brainstem' (3), 'brain, cerebellum' (3), 'brain, cerebral cortex' (3), 'brain, forebrain' (4), 'neuron, cerebellar granule'-brain (5), brain (6), PC-12 (chromaffin) (2), PC-12 (chromaffin) [TrkA (rat), transfection] (2)

Controlled by
Treatments: anoxia (5)



References

1

Nie J, Duan L, Yan Z, Niu Q (2013) Tau hyperphosphorylation is associated with spatial learning and memory after exposure to benzo[a]pyrene in SD rats. Neurotox Res 24, 461-71
23508864   Curated Info

2

Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA (2012) The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells. Mol Cell Proteomics 11, 15-30
22027198   Curated Info

3

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

4

Edbauer D, et al. (2009) Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody. Mol Cell Proteomics 8, 681-95
19054758   Curated Info

5

Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info

6

Watanabe A, et al. (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268, 25712-7
8245007   Curated Info

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