Ser552
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Phosphorylation Site Page:
Ser552 - CTNNB1 (mouse)

Site Information
QDTQRRtsMGGtQQQ   SwissProt Entrez-Gene
Predicted information:  Scansite
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 472273

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (22), mass spectrometry (1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 19, 20, 21, 23), microscopy-colocalization with upstream kinase (15), phospho-antibody (15, 17, 18, 22), western blotting (17, 18)
Disease tissue studied: anthrax infection (14), melanoma skin cancer (21), Cowden disease (22)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (1, 3, 6), 'brain, cerebral cortex' (18, 20), brain (10, 16), C2C12 (myoblast) (11), epithelial (17), epithelial [PIK3R1 (mouse), homozygous knockout] (15), heart (7), intestine (22), liver (5, 9, 23), liver [leptin (mouse), homozygous knockout] (9), MC3T3-E1 (preosteoblast) (2), MEF (fibroblast) (8, 13), MEF (fibroblast) [p53 (mouse), homozygous knockout] (12), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (13), mpkCCD (renal) (19), skin [mGluR1 (mouse), transgenic, TG mutant mice] (21), spleen (14)

Controlled by
Regulatory protein: IFNG (mouse) (17), PIK3R1 (mouse) (15), PTEN (mouse) (22)
Putative in vivo kinases: Akt1 (mouse) (18)
Kinases, in vitro: Akt1 (human) (22)
Treatments: anti-CD3 (15), IL-22 (17), IL-6 (17), inflammation (17), LY294002 (15), piroxicam (15), PTH(1-34) (2), triciribine (17, 18)

Downstream Regulation
Effects of modification on CTNNB1: intracellular localization (22)
Effects of modification on biological processes: transcription, altered (18)

Disease / Diagnostics Relevance
Relevant diseases: Cowden disease (22)

References

1

Minard AY, et al. (2016) mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes. Cell Rep 17, 29-36
27681418   Curated Info

2

Williams GR, et al. (2016) Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods 92, 36-50
26160508   Curated Info

3

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

6

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

7

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

8

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

9

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

10

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

11

Knight JD, et al. (2012) A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts. Skelet Muscle 2, 5
22394512   Curated Info

12

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

13

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

14

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

15

Lee G, et al. (2010) Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139, 869-81, 881.e1-9
20580720   Curated Info

16

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

17

Nava P, et al. (2010) Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32, 392-402
20303298   Curated Info

18

Zhang J, et al. (2010) Cortical neural precursors inhibit their own differentiation via N-cadherin maintenance of beta-catenin signaling. Dev Cell 18, 472-9
20230753   Curated Info

19

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

20

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

21

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

22

He XC, et al. (2007) PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 39, 189-98
17237784   Curated Info

23

Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93
17242355   Curated Info

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