Ser174
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Phosphorylation Site Page:
Ser174 - TPM1 (human)

Site Information
RKLVIIEsDLERAEE   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: TPM1 (mouse): S174, TPM1 (rat): S174, TPM1 iso5 (human): (S138), TPM1 iso10 (human): (S174), TPM1 iso6 (human): (S174), TPM1 iso3 (mouse): (S174), TPM1 iso10 (mouse): (S138), TPM1 iso2 (mouse): (S174), TPM1 (pig): (S174), TPM1 iso2 (human): (S118), TPM1 iso4 (mouse): (S174), TPM1 iso3 (human): (S174), TPM1 (rabbit): (S174)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471100

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 7)
Disease tissue studied: breast cancer (3), breast ductal carcinoma (3), HER2 positive breast cancer (1), luminal A breast cancer (1), luminal B breast cancer (1), breast cancer, surrounding tissue (1), breast cancer, triple negative (1, 3), lung cancer (2), non-small cell lung adenocarcinoma (2)
Relevant cell line - cell type - tissue: 'muscle, skeletal' (5, 7), breast (1, 3), liver (4), PC9 (pulmonary) (2), PC9-IR (pulmonary) (2)




References

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

5

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

6

Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3
21406692   Curated Info

7

Højlund K, et al. (2009) In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS. J Proteome Res 8, 4954-65
19764811   Curated Info

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