Ser338
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Phosphorylation Site Page:
Ser338 - RAF1 (rat)

Site Information
RPRGQRDsSYYWEIE   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: RAF1 (human): S338, RAF1 (mouse): S338, RAF1 (chicken): S338
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447742

In vivo Characterization
Methods used to characterize site in vivo: phospho-antibody (1, 2, 3, 4), western blotting (1, 2)
Relevant cell line - cell type - tissue: 'brain, striatum' (1), mesangial (2), myocyte (4), PC-12 (chromaffin) (3)

Controlled by
Treatments: cytochalasin D (2), GW 5074 (2), LY294002 (2), mechanical stress (2), NGF (3), okadaic acid (1), wortmannin (2), Y27632 (2)



References

1

Mao L, et al. (2005) Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons. J Biol Chem 280, 12602-10
15661743   Curated Info

2

Krepinsky JC, et al. (2005) Stretch-induced Raf-1 activation in mesangial cells requires actin cytoskeletal integrity. Cell Signal 17, 311-20
15567062   Curated Info

3

Hekman M, et al. (2004) Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites. J Biol Chem 279, 14074-86
14688280   Curated Info

4

Clerk A, et al. (2001) Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1. Mol Cell Biol 21, 1173-84
11158304   Curated Info

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