Phosphorylation Site Page:
In vivo Characterization
Methods used to characterize site
mutation of modification site ( 2)
Relevant cell line - cell type - tissue:
HeLa (cervical) [AP2M1 (rat)] ( 2)
Effects of modification on AP2M1:
intracellular localization ( 2), molecular association, regulation ( 1), protein conformation ( 1)
Induce interaction with:
TGOLN2 (human) ( 1)
Höning S, et al. (2005) Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.
Mol Cell 18, 519-31
Olusanya O, Andrews PD, Swedlow JR, Smythe E (2001) Phosphorylation of threonine 156 of the mu2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo.
Curr Biol 11, 896-900