Ser686
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Phosphorylation Site Page:
Ser686 - CD44 (human)

Site Information
KKkLVINsGNGAVED   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CD44 (rat): S447, CD44 iso10 (human): (S437), CD44 iso12 (human): (S305), CD44 iso30 (human): (S686), CD44 iso2 (mouse): (G307), CD44 (mouse): (G722)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 470222

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
Disease tissue studied: breast cancer (7), cervical cancer (12), cervical adenocarcinoma (12), lung cancer (4, 7), non-small cell lung cancer (7), non-small cell lung adenocarcinoma (4), melanoma skin cancer (1)
Relevant cell line - cell type - tissue: A498 (renal) (11), A549 (pulmonary) (5), BT-20 (breast cell) (7), BT-549 (breast cell) (7), GM00130 (B lymphocyte) (10), H1395 (pulmonary) (7), HCC1359 (pulmonary) (7), HCC4006 (pulmonary) (7), HeLa (cervical) (2, 6, 8, 13, 15), HeLa S3 (cervical) (12), HeLa_Meta (cervical) (9), HeLa_Pro (cervical) (9), HeLa_Telo (cervical) (9), lung (4), MDA-MB231 (breast cell) (7), MDA-MB468 (breast cell) (7), NCI-H2030 (pulmonary) (7), NCI-H520 (squamous) (7), PC9 (pulmonary) (7), TERT20 ('stem, mesenchymal') (14), WM239A (epidermal) (1)

Controlled by
Treatments: ionizing_radiation (10), MG132_withdrawal (9), nocodazole (12)



References

1

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

5

Kim JY, et al. (2013) Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells. Proc Natl Acad Sci U S A 110, 12414-9
23836654   Curated Info

6

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

7

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

8

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

9

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info

10

Bennetzen MV, et al. (2010) Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics 9, 1314-23
20164059   Curated Info

11

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

12

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

13

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

14

Thingholm TE, et al. (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res 7, 3304-3313
18578522   Curated Info

15

Olsen JV, et al. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127, 635-48
17081983   Curated Info

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