Ser1164
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Phosphorylation Site Page:
Ser1164 - MYBBP1A (mouse)

Site Information
DIPSDTQsPVSTKRK   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: MYBBP1A (human): S1163, MYBBP1A (rat): S1166, MYBBP1A iso2 (human): (S1163)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453935

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
Disease tissue studied: leukemia (6), acute myelogenous leukemia (6)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (2), 'stem, embryonic' (10), 32Dcl3 (myeloid) (11), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (11), 3T3 (fibroblast) (13), blood (6), Hepa 1-6 (epithelial) (12), liver (1, 5, 9), liver [leptin (mouse), homozygous knockout] (5), lung (9), macrophage-peritoneum (4), MEF (fibroblast) (3, 4, 8), MEF (fibroblast) [p53 (mouse), homozygous knockout] (7), MEF (fibroblast) [Raptor (mouse), knockdown] (3), MEF (fibroblast) [RICTOR (mouse), knockdown] (3), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (8), pancreas (9), spleen (9), testis (9)

Controlled by
Regulatory protein: Raptor (mouse) (3), RICTOR (mouse) (3)



References

1

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

2

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

3

Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3
23429704   Curated Info

4

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

5

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

6

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

7

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

8

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

9

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

10

(2009) CST Curation Set: 8607; Year: 2009; Biosample/Treatment: cell line, embryonic stem cells (mouse)(PTEN)/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-(s/t)P(phosphorylation)
Curated Info

11

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

12

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

13

Wang Z, Gucek M, Hart GW (2008) Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A 105, 13793-8
18779572   Curated Info

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