Tyr701
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Phosphorylation Site Page:
Tyr701 - STAT1 (rat)

Site Information
DDPKRTGyIKTELIS   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: STAT1 (mouse): Y701, STAT1 (human): Y701, STAT1 iso2 (human): (Y701)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447754

In vivo Characterization
Methods used to characterize site in vivo: electrophoretic mobility shift (7), mutation of modification site (13), phospho-antibody (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15), western blotting (3, 5, 10, 11, 12, 13, 14, 15)
Disease tissue studied: liver cancer (11)
Relevant cell line - cell type - tissue: 'brain, cerebral cortex' (10), 'muscle, skeletal' (9), 'neuron, cerebellar granule'-brain (8), astrocyte-'brain, striatum' (5), FRTL-5 (thyroid cell) (12, 15), granulosa (14), H4IIe (hepatic) (11), heart (3), hepatocyte-liver (7), HIT (pancreatic) (6), liver (9), myocyte-heart (4, 13), RAEC (endothelial) (2), RIN (epithelial) (6), U3A (fibroblast) (13)

Controlled by
Regulatory protein: LEPR (mouse) (6), SOCS1 (mouse) (15), SOCS3 (mouse) (15)
Treatments: AG490 (5, 7, 10), fludarabine (7), forskolin (15), G-CSF (4), ganglioside (10), GH (6, 9), H2O2 (5, 12), hypoxia/reoxygenation (7), IFN-gamma (3, 5, 12, 15), IL-10 (5), IL-22 (11), IL-6 (5, 6), ischemia/reperfusion (3, 8), leptin (6), methimazole (12), NAC (7), oxysterol (2), pregnancy (14), PRL (14), rottlerin (14), sepsis (9), tempol (3), TSH (15)

Downstream Regulation
Effects of modification on STAT1: activity, induced (7)
Effects of modification on biological processes: apoptosis, inhibited (7), transcription, altered (7, 13)


References

1

Sandoval-Usme MC, et al. (2014) Simvastatin impairs growth hormone-activated signal transducer and activator of transcription (STAT) signaling pathway in UMR-106 osteosarcoma cells. PLoS One 9, e87769
24489959   Curated Info

2

Romeo GR, Kazlauskas A (2008) Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J Biol Chem 283, 9595-605
18230613   Curated Info

3

McCormick J, et al. (2006) Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury. FASEB J 20, 2115-7
16935931   Curated Info

4

Harada M, et al. (2005) G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 11, 305-11
15723072   Curated Info

5

Gorina R, Petegnief V, Chamorro A, Planas AM (2005) AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway. J Neurochem 92, 505-18
15659221   Curated Info

6

Hekerman P, et al. (2005) Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J 272, 109-19
15634336   Curated Info

7

Terui K, et al. (2004) Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction. Biochem J 380, 203-9
14984365   Curated Info

8

West DA, et al. (2004) MR image-guided investigation of regional signal transducers and activators of transcription-1 activation in a rat model of focal cerebral ischemia. Neuroscience 127, 333-9
15262323   Curated Info

9

Hong-Brown LQ, et al. (2003) Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Am J Physiol Endocrinol Metab 285, E63-72
12644450   Curated Info

10

Kim OS, Park EJ, Joe EH, Jou I (2002) JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. J Biol Chem 277, 40594-601
12191995   Curated Info

11

Lejeune D, et al. (2002) Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. J Biol Chem 277, 33676-82
12087100   Curated Info

12

Kim H, et al. (2001) Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. Mol Pharmacol 60, 972-80
11641425   Curated Info

13

Stephanou A, et al. (2001) Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701. J Biol Chem 276, 28340-7
11309387   Curated Info

14

Peters CA, et al. (2000) Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. Mol Endocrinol 14, 576-90
10770494   Curated Info

15

Park ES, et al. (2000) Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells. Mol Endocrinol 14, 440-8
10707961   Curated Info

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