Ser721
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Phosphorylation Site Page:
Ser721 - p90RSK (mouse)

Site Information
RRVRKLPsTTL____   SwissProt Entrez-Gene
Orthologous residues: p90RSK (human): S732, p90RSK (chicken): (S749), p90RSK (rat): S732, p90RSK iso2 (human): (S741), p90RSK iso3 (mouse): (‑)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447991

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4)
Disease tissue studied: neuroblastoma (2), testicular cancer (3)
Relevant cell line - cell type - tissue: 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (4), F9 (testicular) (3), macrophage-peritoneum (1), N1E-115 (neuron) (2)




References

1

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

2

Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597   Curated Info

3

(2010) CST Curation Set: 9665; Year: 2010; Biosample/Treatment: cell line, F9/untreated; Disease: testicular cancer; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-RXX(s/t)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

4

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

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