Thr726
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Phosphorylation Site Page:
Thr726 - CD44 (mouse)

Site Information
VINGGNGtVEDRKPS   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CD44 (rat): T451, CD44 iso10 (human): (A441), CD44 iso12 (human): (A309), CD44 iso30 (human): (A690), CD44 iso2 (mouse): (T311), CD44 (human): (A690)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4703290

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8)
Disease tissue studied: leukemia (3), acute myelogenous leukemia (3), melanoma skin cancer (8)
Relevant cell line - cell type - tissue: blood (3), liver (2), liver [leptin (mouse), homozygous knockout] (2), MEF (fibroblast) [p53 (mouse), homozygous knockout] (4), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (5), RAW 267.4 (macrophage) (7), skin [mGluR1 (mouse), transgenic, TG mutant mice] (8), spleen (6), stromal (1)

Controlled by
Treatments: IFN-gamma (7)



References

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

3

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

4

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

5

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

6

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

7

Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
19144319   Curated Info

8

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

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