Ser733
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Phosphorylation Site Page:
Ser733 - CD44 (mouse)

Site Information
TVEDRKPsELNGEAS   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CD44 (human): S697, CD44 (rat): S458, CD44 iso10 (human): (S448), CD44 iso12 (human): (S316), CD44 iso30 (human): (S697), CD44 iso2 (mouse): (S318)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465669

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
Disease tissue studied: anthrax infection (9), leukemia (7), acute myelogenous leukemia (7), melanoma skin cancer (13)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (4), 3T3 (fibroblast) [CDC42 (human), transfection] (3), blood (7), Hepa 1-6 (epithelial) (14), liver (6), liver [leptin (mouse), homozygous knockout] (6), lung (10), macrophage-bone marrow (11), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (11), macrophage-peritoneum [RIP3 (mouse), homozygous knockout] (5), MC3T3-E1 (preosteoblast) (1), MEF (fibroblast) [p53 (mouse), homozygous knockout] (8), RAW 267.4 (macrophage) (12), skin [mGluR1 (mouse), transgenic, TG mutant mice] (13), spleen (9, 10), stromal (2)

Controlled by
Regulatory protein: CDC42 (mouse) (3), KRas (mouse) (3), PAK4 (mouse) (3)
Treatments: insulin (4), LPS (11), LY294002 (4), PTH(1-34) (1)



References

1

Williams GR, et al. (2015) Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods
26160508   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Gnad F, et al. (2013) Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics. Mol Cell Proteomics 12, 2070-80
23608596   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

6

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

7

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

8

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

9

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

10

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

11

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

12

Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
19144319   Curated Info

13

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

14

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

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