Ser718
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Phosphorylation Site Page:
Ser718 - CD44 (human)

Site Information
HLVNkEssEtPDQFM   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CD44 (mouse): S754, CD44 iso10 (human): (S469), CD44 iso12 (human): (S337), CD44 iso30 (human): (S718), CD44 iso2 (mouse): (S339), CD44 (rat): (T479)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4148998

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6)
Disease tissue studied: breast cancer (2), breast ductal carcinoma (2), breast cancer, triple negative (2), lung cancer (3), non-small cell lung adenocarcinoma (3)
Relevant cell line - cell type - tissue: breast (2), HeLa (cervical) (1, 4, 6), lung (3), TERT20 ('stem, mesenchymal') (5)




References

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

4

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

5

Thingholm TE, et al. (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res 7, 3304-3313
18578522   Curated Info

6

Ruse CI, et al. (2008) Motif-specific sampling of phosphoproteomes. J Proteome Res 7, 2140-50
18452278   Curated Info

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