Ser37
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Phosphorylation Site Page:
Ser37 - CTNNB1 (mouse)

Site Information
YLDsGIHsGATtTAP   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CTNNB1 (human): S37, CTNNB1 (rat): S37
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447582

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (1, 16), mutation of modification site (1, 7, 13, 16), phospho-antibody (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14), western blotting (1, 2, 5, 6, 7, 8, 9, 10, 11, 12, 16)
Disease tissue studied: leukemia (3), acute myelogenous leukemia (3), neuroblastoma (16)
Relevant cell line - cell type - tissue: 'brain, striatum' (14), 'neuron, cortical'-brain (5), 'neuron, hippocampal'-brain (5), 293 (epithelial) (7), 293T (epithelial) (6), 3T3 (fibroblast) (1), brain (8), brain [CDK5R1 (mouse)] (8), E14tg2a ('stem, embryonic') (12), epithelial [PIK3R1 (mouse), homozygous knockout] (4), intestine [CK1A (mouse), homozygous knockout] (2), L cells (fibroblast) (10, 11), MEF (fibroblast) [JNK1 (mouse), transfection] (7), Neuro-2A (neuron) (16), stem (3), Swiss 3T3 (fibroblast) (13), uterus (9)

Controlled by
Regulatory protein: CDK5R1 (mouse) (8), CK1A (mouse) (2), CTNNB1 (mouse) (10), DISC1 (human) (5), DISC1 (mouse) (5), HRas (mouse) (1), Huntingtin (mouse) (14), KRas (mouse) (1), PIK3R1 (mouse) (4), ZBED3 (mouse) (6)
Putative upstream kinases: GSK3B (human) (6, 16)
Kinases, in vitro: GSK3B (mouse) (15)
Treatments: differentiation (9), LIF (12), LLnL (16), LY294002 (12), MG132 (10), QLT0267 (11), siRNA (5), Wnt3a (11)

Downstream Regulation
Effects of modification on CTNNB1: protein degradation (13, 16), ubiquitination (16)

Disease / Diagnostics Relevance
Relevant diseases: acute myelogenous leukemia (3)

References

1

Wang MT, et al. (2015) K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling. Cell 163, 1237-51
26590425   Curated Info

2

Elyada E, et al. (2011) CKIα ablation highlights a critical role for p53 in invasiveness control. Nature 470, 409-13
21331045   Curated Info

3

Yeung J, et al. (2010) β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell 18, 606-18
21156284   Curated Info

4

Lee G, et al. (2010) Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139, 869-81, 881.e1-9
20580720   Curated Info

5

Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31
19303846   Curated Info

6

Chen T, et al. (2009) Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/{beta}-Catenin Signaling. J Biol Chem 284, 6683-9
19141611   Curated Info

7

Hu D, et al. (2008) c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis 29, 2317-24
18952597   Curated Info

8

Wen Y, et al. (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28, 2624-32
18322105   Curated Info

9

Herington JL, Bi J, Martin JD, Bany BM (2007) Beta-catenin (CTNNB1) in the mouse uterus during decidualization and the potential role of two pathways in regulating its degradation. J Histochem Cytochem 55, 963-74
17533218   Curated Info

10

Abe K, Takeichi M (2007) NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression. Neuron 53, 387-97
17270735   Curated Info

11

Oloumi A, Syam S, Dedhar S (2006) Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 25, 7747-57
16799642   Curated Info

12

Paling NR, Wheadon H, Bone HK, Welham MJ (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279, 48063-70
15328362   Curated Info

13

Liu J, Farmer SR (2004) Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. J Biol Chem 279, 45020-7
15308623   Curated Info

14

Gines S, et al. (2003) Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. J Biol Chem 278, 50514-22
14522959   Curated Info

15

Sakanaka C (2002) Phosphorylation and regulation of beta-catenin by casein kinase I epsilon. J Biochem (Tokyo) 132, 697-703
12417018   Curated Info

16

Aberle H, et al. (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16, 3797-804
9233789   Curated Info

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