Ser555
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Phosphorylation Site Page:
Ser555 - SH3KBP1 (mouse)

Site Information
PDIFDSPsPEEDKEE   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: SH3KBP1 (human): S511, SH3KBP1 (rat): S555, SH3KBP1 iso2 (human): (S474), SH3KBP1 iso2 (rat): (S511), SH3KBP1 iso3 (mouse): (S474)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3208719

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6)
Disease tissue studied: leukemia (2), acute myelogenous leukemia (2), melanoma skin cancer (6)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (1), 32Dcl3 (myeloid) (5), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (5), blood (2), brain (4), kidney (4), lung (4), MEF (fibroblast) [p53 (mouse), homozygous knockout] (3), skin [mGluR1 (mouse), transgenic, TG mutant mice] (6), spleen (4)

Controlled by
Treatments: insulin (1)



References

1

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

2

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

3

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

4

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

5

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

6

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

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