Ser2716
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Phosphorylation Site Page:
Ser2716 - FAM44A (mouse)

Site Information
RKPDYSSsEEELDDS   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: FAM44A (human): S2780, FAM44A (rat): (T2636)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3150848

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (1), 'brain, embryonic' (8), 32Dcl3 (myeloid) (7), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (7), brain (6), macrophage-bone marrow (5), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (5), MEF (fibroblast) [p53 (mouse), homozygous knockout] (2), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (3), P19 (testicular) (9), testis (4)




References

1

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

2

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

3

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

4

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

5

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

6

Wiƛniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

7

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

8

(2009) CST Curation Set: 7382; Year: 2009; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-QX(s/t)(phosphorylation)
Curated Info

9

Smith JC, et al. (2007) A differential phosphoproteomic analysis of retinoic acid-treated P19 cells. J Proteome Res 6, 3174-86
17622165   Curated Info

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