Ser21
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Phosphorylation Site Page:
Ser21 - UBE1 (mouse)

Site Information
GPDPKPGsNCSPAQS   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: UBE1 (human): S21, UBE1 (rat): (S21)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3182014

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (1), 'fat, brown'-'fat, brown' (4), brain (4), heart (4), kidney (4), liver (4), lung (4), macrophage-peritoneum [RIP3 (mouse), homozygous knockout] (2), MEF (fibroblast) (3), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (3), pancreas (4), spleen (4), testis (4)

Controlled by
Treatments: insulin (1)



References

1

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

2

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

3

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

4

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

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