Ser241
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Phosphorylation Site Page:
Ser241 - ACTA1 (mouse)

Site Information
SSSSLEKsYELPDGQ   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: ACTA1 (human): S241, ACTA1 (rat): S241, ACTA1 (rabbit): (S241)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3147246

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 3, 4, 5, 6, 7, 8, 9, 10)
Disease tissue studied: anthrax infection (6), melanoma skin cancer (9)
Relevant cell line - cell type - tissue: brain (7, 8), heart (3, 7), Hepa 1-6 (epithelial) (10), kidney (7), liver (5), liver [leptin (mouse), homozygous knockout] (5), lung (7), macrophage-peritoneum (4), MC3T3-E1 (preosteoblast) (1), skin [mGluR1 (mouse), transgenic, TG mutant mice] (9), spleen (6, 7)




References

1

Williams GR, et al. (2015) Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods
26160508   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

4

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

5

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

6

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

7

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

8

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

9

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

10

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

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