Thr720
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Phosphorylation Site Page:
Thr720 - CD44 (human)

Site Information
VNKESSEtPDQFMTA   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CD44 (mouse): T756, CD44 iso10 (human): (T471), CD44 iso12 (human): (T339), CD44 iso30 (human): (T720), CD44 iso2 (mouse): (T341), CD44 (rat): (T481)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3177661

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7)
Disease tissue studied: breast cancer (3), breast ductal carcinoma (3), breast cancer, triple negative (3), leukemia (4), acute myelogenous leukemia (4), melanoma skin cancer (1)
Relevant cell line - cell type - tissue: breast (3), HeLa (cervical) (2, 5, 6), KG-1 (myeloid) (4), TERT20 ('stem, mesenchymal') (7), WM239A (epidermal) (1)




References

1

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56
22115753   Curated Info

5

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

6

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

7

Thingholm TE, et al. (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res 7, 3304-3313
18578522   Curated Info

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