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Phosphorylation Site Page:
Ser1217 - INSR (human)

Site Information
DGVFTTSsDMWSFGV   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: INSR (mouse): (S1207), INSR (rat): (S1218), INSR iso2 (human): (S1205)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3103702

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (1), immunoprecipitation (1), mutation of modification site (1), phospho-antibody (1), western blotting (1)
Relevant cell line - cell type - tissue: 293 (epithelial) (1), 3T3 (fibroblast) [INSR (human)] (1)

Downstream Regulation
Effects of modification on INSR: enzymatic activity, induced (1)



Bossenmaier B, et al. (2000) Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation. Diabetes 49, 889-95
10866039   Curated Info

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