Lys14
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Acetylation Site Page:
Lys14 - H3 (rat)

Site Information
ARKSTGGkAPRKQLA   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: H3 (human): K14, H3 (mouse): K14, H3 iso3 (rat): K14, H3 (pig): K14, H3 (chicken): (K14), H3 (cow): (K14), H3 iso3 (mouse): K14, H3 iso2 (mouse): K14
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458954

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (7), mass spectrometry (2), phospho-antibody (7, 8, 10), western blotting (10)
Disease tissue studied: liver cancer (7), hepatocellular carcinoma (7)
Relevant cell line - cell type - tissue: 'brain, hippocampus' (10), 'fat, brown' (2), brain (2), HL1C (hepatocyte) (7), intestine (2), lung (2), RAEC (endothelial) (8), spleen (2)

Controlled by
Treatments: contextual fear conditioning (10), DDTC (10), glucose (7), oxysterol (8), SSZ (10)

Downstream Regulation
Effects of modification on biological processes: chromatin organization, altered (10), transcription, induced (10)


References

1

Blaze J, Asok A, Roth TL (2015) Long-term effects of early-life caregiving experiences on brain-derived neurotrophic factor histone acetylation in the adult rat mPFC. Stress, 1-9
26305287   Curated Info

2

Lundby A, et al. (2012) Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Cell Rep 2, 419-31
22902405   Curated Info

3

Papadopoulos A, et al. (2011) GABAergic control of novelty stress-responsive epigenetic and gene expression mechanisms in the rat dentate gyrus. Eur Neuropsychopharmacol 21, 316-24
20627472   Curated Info

4

Yakovlev A, et al. (2010) Epigenetic regulation of caspase-3 gene expression in rat brain development. Gene 450, 103-8
19909801   Curated Info

5

Kawakami K, et al. (2009) Age-related difference of site-specific histone modifications in rat liver. Biogerontology 10, 415-21
18814051   Curated Info

6

Tian F, et al. (2009) Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1. J Neurochem 109, 1375-88
19476549   Curated Info

7

Eckert DT, et al. (2008) Detailed molecular analysis of the induction of the L-PK gene by glucose. Biochem Biophys Res Commun 372, 131-6
18468514   Curated Info

8

Romeo GR, Kazlauskas A (2008) Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J Biol Chem 283, 9595-605
18230613   Curated Info

9

Ho AK, et al. (2007) Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes. Endocrinology 148, 4592-600
17628002   Curated Info

10

Lubin FD, Sweatt JD (2007) The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. Neuron 55, 942-57
17880897   Curated Info

11

Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622   Curated Info

12

Sahar S, et al. (2007) Cooperation of SRC-1 and p300 with NF-kappaB and CREB in angiotensin II-induced IL-6 expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 27, 1528-34
17495236   Curated Info

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