Tyr1564
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Phosphorylation Site Page:
Tyr1564 - ITGB4 (human)

Site Information
LQGYSVEyQLLNGGE   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: ITGB4 iso2 (human): Y1494, ITGB4 iso3 (mouse): (Y1548), ITGB4 (mouse): (Y1560), ITGB4 iso3 (human): (Y1547), ITGB4 iso2 (mouse): (Y1495), ITGB4 (rat): (Y1548)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456323

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (2), mutation of modification site (3), phospho-antibody (3)
Disease tissue studied: leukemia (2), chronic myelogenous leukemia (2)
Relevant cell line - cell type - tissue: K562 (erythroid) (2), MDA-MB435 (breast cell) (3)

Controlled by
Putative upstream kinases: FGFR1 (human) (1)
Treatments: ECPC (1), vanadate (3)



References

1

Ge D, et al. (2013) Phosphorylation and nuclear translocation of integrin β4 induced by a chemical small molecule contribute to apoptosis in vascular endothelial cells. Apoptosis 18, 1120-31
23677256   Curated Info

2

(2010) CST Curation Set: 9858; Year: 2010; Biosample/Treatment: cell line, K562/normal; Disease: chronic myelogenous leukemia; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Shaw LM (2001) Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion. Mol Cell Biol 21, 5082-93
11438664   Curated Info

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