Tyr364
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Phosphorylation Site Page:
Tyr364 - IL2RB (human)

Site Information
SCFTNQGyFFFHLPD   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: IL2RB (mouse): (Y367)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455360

In vivo Characterization
Methods used to characterize site in vivo: mutation of modification site (1, 3, 4), phospho-antibody (3, 4)
Relevant cell line - cell type - tissue: BaF3 ('B lymphocyte, precursor') (3, 4), COS (fibroblast) (4), CTLL (T lymphocyte) (3), HT-2 (T lymphocyte) (1)

Controlled by
Treatments: IL-2 (3)

Downstream Regulation
Effects of modification on IL2RB: molecular association, regulation (2, 3, 4)
Effects of modification on biological processes: transcription, induced (1)
Induce interaction with: SHC1 (human) (2, 3, 4)


References

1

Lindemann MJ, et al. (2008) Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. J Biol Chem 283, 14100-8
18348982   Curated Info

2

Delespine-Carmagnat M, Bouvier G, Bertoglio J (2000) Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain. Eur J Immunol 30, 59-68
10602027   Curated Info

3

Ravichandran KS, et al. (1996) Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc Natl Acad Sci U S A 93, 5275-80
8643566   Curated Info

4

Evans GA, et al. (1995) Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem 270, 28858-63
7499411   Curated Info

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