Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Phosphorylation Site Page:
Tyr364 - IL2RB (human)

Site Information
SCFTNQGyFFFHLPD   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: IL2RB (mouse): (Y367)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455360

In vivo Characterization
Methods used to characterize site in vivo: mutation of modification site (1, 3, 4), phospho-antibody (3, 4)
Relevant cell line - cell type - tissue: BaF3 ('B lymphocyte, precursor') (3, 4), COS (fibroblast) (4), CTLL (T lymphocyte) (3), HT-2 (T lymphocyte) (1)

Controlled by
Treatments: IL-2 (3)

Downstream Regulation
Effects of modification on IL2RB: molecular association, regulation (2, 3, 4)
Effects of modification on biological processes: transcription, induced (1)
Induce interaction with: SHC1 (human) (2, 3, 4)



Lindemann MJ, et al. (2008) Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. J Biol Chem 283, 14100-8
18348982   Curated Info


Delespine-Carmagnat M, Bouvier G, Bertoglio J (2000) Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain. Eur J Immunol 30, 59-68
10602027   Curated Info


Ravichandran KS, et al. (1996) Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc Natl Acad Sci U S A 93, 5275-80
8643566   Curated Info


Evans GA, et al. (1995) Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem 270, 28858-63
7499411   Curated Info

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.