Tyr132
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Phosphorylation Site Page:
Tyr132 - ZO1 (mouse)

Site Information
SDNEDDSyDEEVHDP   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: ZO1 (human): Y132, ZO1 (rat): Y120, ZO1 iso2 (mouse): (Y132), ZO1 iso2 (human): (Y132)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2020857

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
Disease tissue studied: anthrax infection (5)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (2), brain (7), heart (9, 11), liver (1), MEF (fibroblast) (3, 4, 10), MEF (fibroblast) [PTP1B (mouse), homozygous knockout] (10), MEF (fibroblast) [Raptor (mouse), knockdown] (3), MEF (fibroblast) [RICTOR (mouse), knockdown] (3), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (4), mpkCCD (renal) (8), spleen (5, 6)




References

1

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

2

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

3

Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3
23429704   Curated Info

4

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

5

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

6

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

7

Wiƛniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

8

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

9

(2009) CST Curation Set: 7386; Year: 2009; Biosample/Treatment: tissue, heart/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-QX(s/t)(phosphorylation)
Curated Info

10

Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77
18515860   Curated Info

11

(2007) CST Curation Set: 2923; Year: 2007; Biosample/Treatment: tissue, heart/-; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-(s/t)(D/E)X(D/E)(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho(Ser/Thr) CKII Substrate Antibody (polyAb) Cat#: 5808, PTMScan(R) Phospho-CK Substrate Motif (S*/T*D/EXD/E) Immunoaffinity Beads Cat#: 1994
Curated Info

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