Ser412
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Phosphorylation Site Page:
Ser412 - BZW2 (mouse)

Site Information
LQNAEEEsESEGEES   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: BZW2 (human): S412, BZW2 (rat): S412
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454563

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (1), 'brain, embryonic' (9), 32Dcl3 (myeloid) (8), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (8), heart (2), Hepa 1-6 (epithelial) (10), liver (6), lung (6), macrophage-bone marrow (7), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (7), MEF (fibroblast) (3), MEF (fibroblast) [p53 (mouse), homozygous knockout] (4), MEF (fibroblast) [Raptor (mouse), knockdown] (3), MEF (fibroblast) [RICTOR (mouse), knockdown] (3), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (5), spleen (6)




References

1

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

2

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

3

Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3
23429704   Curated Info

4

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

5

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

6

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

7

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

8

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

9

(2009) CST Curation Set: 7381; Year: 2009; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-QX(s/t)(phosphorylation)
Curated Info

10

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

11

Ballif BA, et al. (2004) Phosphoproteomic analysis of the developing mouse brain. Mol Cell Proteomics 3, 1093-101
15345747   Curated Info

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