Ser376
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Phosphorylation Site Page:
Ser376 - HDGF2 iso3 (mouse)

Site Information
RAERGGSsGEELEDE   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: HDGF2 (rat): S367, HDGF2 (human): S370, HDGF2 iso2 (mouse): (S366), HDGF2 iso2 (human): (S370), HDGF2 (mouse): S367
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454542

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
Disease tissue studied: melanoma skin cancer (7)
Relevant cell line - cell type - tissue: 'brain, forebrain' (9), 'fat, brown'-'fat, brown' (2), brain (2, 4), heart (2), Hepa 1-6 (epithelial) (8), kidney (2), liver (2), lung (2), macrophage-bone marrow (3), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (3), MEF (fibroblast) [p53 (mouse), homozygous knockout] (1), mpkCCD (renal) (5), P19 (testicular) (10), pancreas (2), RAW 267.4 (macrophage) (6), skin [mGluR1 (mouse), transgenic, TG mutant mice] (7), spleen (2), testis (2)




References

1

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

3

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

4

Wiƛniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

5

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

6

Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
19144319   Curated Info

7

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

8

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

9

Collins MO, et al. (2008) Phosphoproteomic analysis of the mouse brain cytosol reveals a predominance of protein phosphorylation in regions of intrinsic sequence disorder. Mol Cell Proteomics 7, 1331-48
18388127   Curated Info

10

Smith JC, et al. (2007) A differential phosphoproteomic analysis of retinoic acid-treated P19 cells. J Proteome Res 6, 3174-86
17622165   Curated Info

11

Ballif BA, et al. (2004) Phosphoproteomic analysis of the developing mouse brain. Mol Cell Proteomics 3, 1093-101
15345747   Curated Info

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