Ser307
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Phosphorylation Site Page:
Ser307 - DCAMKL1 (mouse)

Site Information
GPSRRSKsPASTSSV   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: DCAMKL1 (human): S307, DCAMKL1 iso2 (mouse): S307, DCAMKL1 iso2 (human): (S307), DCAMKL1 iso3 (mouse): (S359), DCAMKL1 iso5 (human): (S307), DCAMKL1 (rat): (‑)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454213

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
Disease tissue studied: neuroblastoma (7), melanoma skin cancer (9)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (1, 3), 'brain, cerebral cortex' (12), 'brain, embryonic' (10, 11), brain (8), lung (8), MEF (fibroblast) (4, 6), MEF (fibroblast) [p53 (mouse), homozygous knockout] (5), N1E-115 (neuron) (7), skin [mGluR1 (mouse), transgenic, TG mutant mice] (9), spleen (8), stromal (2)

Controlled by
Regulatory protein: TSC2 (mouse) (5)
Treatments: insulin (3), LPA (7)



References

1

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

4

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

5

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

6

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

7

Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597   Curated Info

8

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

9

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

10

(2008) CST Curation Set: 4781; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-tXR(phosphorylation) Antibody Used to Purify Peptides prior to MS2: Phospho-Threonine-X-Arginine Antibody Cat#: 2351, PTMScan(R) Phospho-Thr-X-Arg Motif (T*XR) Immunoaffinity Beads Cat#: 1988
Curated Info

11

(2008) CST Curation Set: 3808; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-(s/t)P(phosphorylation) , PTMScan(R) PLK Binding Motif (SpTP) Immunoaffinity Beads Cat#: 1995
Curated Info

12

Munton RP, et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics 6, 283-93
17114649   Curated Info

13

Ballif BA, et al. (2004) Phosphoproteomic analysis of the developing mouse brain. Mol Cell Proteomics 3, 1093-101
15345747   Curated Info

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