Ser307
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Phosphorylation Site Page:
Ser307 - DCAMKL1 (mouse)

Site Information
GPSRRSKsPASTSSV   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: DCAMKL1 (human): S307, DCAMKL1 iso2 (mouse): S307, DCAMKL1 iso2 (human): (S307), DCAMKL1 iso3 (mouse): (S359), DCAMKL1 iso5 (human): (S307), DCAMKL1 (rat): (‑)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454213

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
Disease tissue studied: neuroblastoma (6), melanoma skin cancer (8)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (1, 2), 'brain, cerebral cortex' (11), 'brain, embryonic' (9, 10), brain (7), lung (7), MEF (fibroblast) (3, 5), MEF (fibroblast) [p53 (mouse), homozygous knockout] (4), N1E-115 (neuron) (6), skin [mGluR1 (mouse), transgenic, TG mutant mice] (8), spleen (7)

Controlled by
Regulatory protein: TSC2 (mouse) (4)
Treatments: insulin (2), LPA (6)



References

1

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

2

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

3

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

4

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

5

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

6

Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597   Curated Info

7

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

8

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

9

Zhou J (2008) CST Curation Set: 4781; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pTXR Antibodies Used to Purify Peptides prior to LCMS: Phospho-Threonine-X-Arginine Antibody Cat#: 2351, PTMScan(R) Phospho-Thr-X-Arg Motif (T*XR) Immunoaffinity Beads Cat#: 1988
Curated Info

10

Zhou J (2008) CST Curation Set: 3808; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P , PTMScan(R) PLK Binding Motif (SpTP) Immunoaffinity Beads Cat#: 1995
Curated Info

11

Munton RP, et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics 6, 283-93
17114649   Curated Info

12

Ballif BA, et al. (2004) Phosphoproteomic analysis of the developing mouse brain. Mol Cell Proteomics 3, 1093-101
15345747   Curated Info

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