Ser1034
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Phosphorylation Site Page:
Ser1034 - INSR (rat)

Site Information
LRELGQGsFGMVYEG   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: INSR (human): S1033, INSR iso2 (human): (S1021), INSR (mouse): (S1023)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454090

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (2), phospho-antibody (1, 2, 3), western blotting (1)
Relevant cell line - cell type - tissue: 'muscle, skeletal' (3), liver (1, 2, 3)

Controlled by
Regulatory protein: INSR (rat) (3)
Putative upstream kinases: TBK1 (rat) (1)
Kinases, in vitro: TBK1 (human) (1)
Treatments: insulin (1, 2, 3), irbesartan (1, 2), TNF (1)



References

1

Muñoz MC, et al. (2009) TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. J Endocrinol 201, 185-97
19251743   Curated Info

2

Muñoz MC, et al. (2006) Irbesartan restores the in-vivo insulin signaling pathway leading to Akt activation in obese Zucker rats. J Hypertens 24, 1607-17
16877964   Curated Info

3

Coba MP, et al. (2004) Increased in vivo phosphorylation of insulin receptor at serine 994 in the liver of obese insulin-resistant Zucker rats. J Endocrinol 182, 433-44
15350185   Curated Info

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