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Phosphorylation Site Page:
Tyr349 - Kv7.3 iso2 (rat)

Site Information
IQAAWRYyATNPNRL   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: Kv7.3 (rat): Y387, Kv7.3 iso3 (mouse): (Y384), Kv7.3 (mouse): (Y387), Kv7.3 (human): (Y386)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 453409

In vivo Characterization
Methods used to characterize site in vivo: mutation of modification site (1), phospho-antibody (1), western blotting (1)
Relevant cell line - cell type - tissue: CHO (fibroblast) [EphB1 (human), transfection] (1)

Controlled by
Putative upstream kinases: Src (rat) (1)

Downstream Regulation
Effects of modification on Kv7.3 iso2: activity, inhibited (1)



Li Y, et al. (2004) Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. J Biol Chem 279, 45399-407
15304482   Curated Info

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