Ser461
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Phosphorylation Site Page:
Ser461 - Bcr (mouse)

Site Information
GLPYIDDsPSSSPHL   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: Bcr (human): S459, Bcr (rat): S461, Bcr iso2 (human): (S459)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448868

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
Disease tissue studied: melanoma skin cancer (11)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (4), 'fat, brown'-'fat, brown' (9), brain (5, 6, 9, 10), Hepa 1-6 (epithelial) (12), kidney (9), liver (3, 13), lung (9), MC3T3-E1 (preosteoblast) (1), MEF (fibroblast) (8), MEF (fibroblast) [p53 (mouse), homozygous knockout] (7), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (8), skin [mGluR1 (mouse), transgenic, TG mutant mice] (11), spleen (9), testis (9)

Controlled by
Treatments: PTH(1-34) (1)



References

1

Williams GR, et al. (2015) Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods
26160508   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86
23567750   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

6

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

7

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

8

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

9

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

10

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

11

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

12

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

13

Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93
17242355   Curated Info

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