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Phosphorylation Site Page:
Ser1360 - ITGB4 (human)

Site Information
VLRSPSGsQRPSVSD   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: ITGB4 iso3 (mouse): (S1362), ITGB4 (mouse): (S1362), ITGB4 iso3 (human): S1360, ITGB4 iso2 (mouse): (S1362), ITGB4 iso2 (human): S1360, ITGB4 (rat): (S1362)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451654

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (3, 4), immunoprecipitation (3), mutation of modification site (1, 2, 3), phospho-antibody (1, 3), phosphopeptide mapping (3, 4), western blotting (1, 3)
Disease tissue studied: PA-JEB (1)
Relevant cell line - cell type - tissue: 804G (epithelial) (2), COS (fibroblast) (1, 3), COS (fibroblast) [ITGA6 (human)] (4), HaCaT (keratinocyte) (4), PA-JEB (keratinocyte) (1)

Controlled by
Putative upstream kinases: PKCA (human) (3)
Kinases, in vitro: PKCA (human) (4)
Treatments: EGF (1, 3, 4), Go_6983 (3), phorbol_ester (1, 3)

Downstream Regulation
Effects of modification on ITGB4: molecular association, regulation (3)
Inhibit interaction with: Plectin-1 (human) (3)



Frijns E, et al. (2010) EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4. J Biol Chem 285, 37650-62
20870721   Curated Info


Germain EC, Santos TM, Rabinovitz I (2009) Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Mol Biol Cell 20, 56-67
19005215   Curated Info


Wilhelmsen K, et al. (2007) Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol Biol Cell 18, 3512-22
17615294   Curated Info


Rabinovitz I, Tsomo L, Mercurio AM (2004) Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Mol Cell Biol 24, 4351-60
15121854   Curated Info

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