Ser1333
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Phosphorylation Site Page:
Ser1333 - INSR (human)

Site Information
NVPLDRSsHCQREEA   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: INSR (rat): (S1334), INSR iso2 (human): (S1321), INSR (mouse): (S1323)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451591

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (1, 2), phosphoamino acid analysis (1, 2), phosphopeptide mapping (1, 2)
Relevant cell line - cell type - tissue: 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] (2), CHO (fibroblast) [EphB1 (human), transfection] (1)

Controlled by
Regulatory protein: PKCA (cow) (1), PKCB (cow) (1), PKCE (human) (1), PKCG (human) (1)
Treatments: insulin (1, 2), phorbol ester (1)

Downstream Regulation
Effects of modification on INSR: enzymatic activity, inhibited (1)


References

1

Chin JE, Dickens M, Tavare JM, Roth RA (1993) Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling. J Biol Chem 268, 6338-47
8454604   Curated Info

2

Lewis RE, Wu GP, MacDonald RG, Czech MP (1990) Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase. J Biol Chem 265, 947-54
2136851   Curated Info

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.