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Phosphorylation Site Page:
Ser1333 - INSR (human)

Site Information
NVPLDRSsHCQREEA   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: INSR (mouse): (S1323), INSR iso2 (human): (S1321), INSR (rat): (S1334)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451591

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (1, 2), phosphoamino acid analysis (1, 2), phosphopeptide mapping (1, 2)
Relevant cell line - cell type - tissue: 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] (2), CHO (fibroblast) [EphB1 (human), transfection] (1)

Controlled by
Regulatory protein: PKCA (cow) (1), PKCB (cow) (1), PKCE (human) (1), PKCG (human) (1)
Treatments: insulin (1, 2), phorbol_ester (1)

Downstream Regulation
Effects of modification on INSR: enzymatic activity, inhibited (1)



Chin JE, Dickens M, Tavare JM, Roth RA (1993) Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling. J Biol Chem 268, 6338-47
8454604   Curated Info


Lewis RE, Wu GP, MacDonald RG, Czech MP (1990) Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase. J Biol Chem 265, 947-54
2136851   Curated Info

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