Ser1062
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Phosphorylation Site Page:
Ser1062 - INSR (human)

Site Information
AVKTVNEsASLRERI   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: INSR (mouse): S1052, INSR iso2 (human): (S1050), INSR (rat): (S1063)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451562

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (3), electrophoretic mobility shift (3), immunoprecipitation (2), mutation of modification site (2, 3), phosphopeptide mapping (3), western blotting (2)
Relevant cell line - cell type - tissue: 293 (epithelial) (2), CHO (fibroblast) [EphB1 (human), transfection] (3)

Controlled by
Regulatory protein: PKCB iso2 (human) (2), PKCH (human) (2)
Kinases, in vitro: PKCA (human) (3)
Treatments: phorbol_ester (3)

Downstream Regulation
Effects of modification on INSR: phosphorylation (2)


References

1

Coba MP, Turyn D, Peña C (2003) Synthesis and immunogenic properties of phosphopeptides related to the human insulin receptor. J Pept Res 61, 17-23
12472845   Curated Info

2

Strack V, et al. (2000) Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta. Diabetologia 43, 443-9
10819237   Curated Info

3

Liu F, Roth RA (1994) Identification of serines-1035/1037 in the kinase domain of the insulin receptor as protein kinase C alpha mediated phosphorylation sites. FEBS Lett 352, 389-92
7926007   Curated Info

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