Ser742
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Phosphorylation Site Page:
Ser742 - CD44 (mouse)

Site Information
LNGEASKsQEMVHLV   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: CD44 (human): S706, CD44 (rat): S467, CD44 iso2 (mouse): S327, CD44 iso30 (human): (S706), CD44 iso12 (human): S325, CD44 iso10 (human): (S457)
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450988

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
Disease tissue studied: leukemia (8), acute myelogenous leukemia (8), melanoma skin cancer (15)
Relevant cell line - cell type - tissue: '3T3-L1, differentiated' (adipocyte) (2, 4), 32Dcl3 (myeloid) (13), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (13), blood (8), brain (9, 11), heart (5), Hepa 1-6 (epithelial) (16), lung (11), macrophage-bone marrow (12), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (12), macrophage-peritoneum (7), macrophage-peritoneum [RIP3 (mouse), homozygous knockout] (7), MC3T3-E1 (preosteoblast) (1), MEF (fibroblast) (6, 10), MEF (fibroblast) [Raptor (mouse), knockdown] (6), MEF (fibroblast) [RICTOR (mouse), knockdown] (6), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (10), RAW 267.4 (macrophage) (14), skin [mGluR1 (mouse), transgenic, TG mutant mice] (15), spleen (11)

Controlled by
Regulatory protein: Raptor (mouse) (6)
Treatments: LPS (12)



References

1

Williams GR, et al. (2015) Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods
26160508   Curated Info

2

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

6

Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3
23429704   Curated Info

7

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

8

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

9

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

10

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

11

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

12

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

13

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

14

Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
19144319   Curated Info

15

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

16

Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46
18846507   Curated Info

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