Thr287
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Home > Phosphorylation Site Page: > Thr287  -  CAMK2D (rat)

Site Information
sMMHRQEtVDCLkkF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450982

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 5 ) , mass spectrometry ( 3 ) , mutation of modification site ( 6 ) , phospho-antibody ( 1 , 2 , 6 ) , western blotting ( 1 , 2 , 6 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 3 ) , 'muscle, smooth'-thoracic aorta ( 6 ) , heart ( 2 ) , muscle ( 3 ) , myocyte-heart ( 1 , 5 ) , spleen ( 3 ) , thymus ( 3 )

Upstream Regulation
Putative in vivo kinases:
CAMK2D (rat) ( 5 , 6 )
Kinases, in vitro:
CAMK2D (rat) ( 4 )
Treatments:
Diacetylmorphine ( 1 ) , electrical_stimulation ( 5 ) , ionomycin ( 6 ) , KN-93 ( 1 , 6 ) , myocarditis ( 2 ) , okadaic_acid ( 5 ) , prednisolone ( 2 )

Downstream Regulation
Effects of modification on CAMK2D:
enzymatic activity, induced ( 6 )
Effects of modification on biological processes:
cell motility, altered ( 6 )

References 

1

Ji M, et al. (2023) CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms. Sci Rep 13, 5827
37037889   Curated Info

2

Park H, et al. (2014) Increased phosphorylation of ca(2+) handling proteins as a proarrhythmic mechanism in myocarditis. Circ J 78, 2292-301
25056499   Curated Info

3

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

4

Grueter CE, et al. (2008) Differential Regulated Interactions of Calcium/Calmodulin-Dependent Protein Kinase II with Isoforms of Voltage-Gated Calcium Channel beta Subunits. Biochemistry 47, 1760-7
18205403   Curated Info

5

Huke S, Bers DM (2007) Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII. J Mol Cell Cardiol 42, 590-9
17239900   Curated Info

6

Pfleiderer PJ, et al. (2004) Modulation of vascular smooth muscle cell migration by calcium/ calmodulin-dependent protein kinase II-delta 2. Am J Physiol Cell Physiol 286, C1238-45
14761894   Curated Info

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