Thr1376
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Phosphorylation Site Page:
Thr1376 - INSR (rat)

Site Information
KKNGRVLtLPRSNPS   SwissProt Entrez-Gene
Predicted information:  Scansite
Orthologous residues: INSR (human): T1375, INSR (mouse): (T1365), INSR iso2 (human): T1363
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450327

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (2), phospho-antibody (1), phosphoamino acid analysis (2), phosphopeptide mapping (2)
Disease tissue studied: liver cancer (2)
Relevant cell line - cell type - tissue: 'muscle, skeletal' (1), H-35 (hepatic) (2), liver (1)

Controlled by
Regulatory protein: INSR (rat) (1)
Kinases, in vitro: PKCA (rat) (2)
Treatments: insulin (1), phorbol ester (2)



References

1

Coba MP, et al. (2004) Increased in vivo phosphorylation of insulin receptor at serine 994 in the liver of obese insulin-resistant Zucker rats. J Endocrinol 182, 433-44
15350185   Curated Info

2

Koshio O, Akanuma Y, Kasuga M (1989) Identification of a phosphorylation site of the rat insulin receptor catalyzed by protein kinase C in an intact cell. FEBS Lett 254, 22-4
2506075   Curated Info

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