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CEP72
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Belongs to the CEP72 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding |
| Chromosomal Location of Human Ortholog: 5p15.33 |
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Cellular Component: centrosome; cytosol
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Molecular Function: protein binding
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Biological Process: centriole replication; G2/M transition of mitotic cell cycle; gamma-tubulin complex localization; spindle organization and biogenesis
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Reference #:
Q9P209
(UniProtKB)
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Alt. Names/Synonyms: centrosomal protein 72kDa; Centrosomal protein of 72 kDa; CEP72; FLJ10565; KIAA1519; MGC5307
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Gene Symbols: CEP72
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Molecular weight:
71,718 Da
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Basal Isoelectric point:
6.08
Predict pI for various phosphorylation states
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