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Protein Page:
Kv7.2 (human)

Kv7.2 Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors. Defects in KCNQ2 are the cause of benign familial neonatal seizures type 1 (BFNS1). A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. Some rare cases manifest an atypical severe phenotype associated with epileptic encephalopathy and psychomotor retardation. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. In some patients, neonatal convulsions are followed later in life by myokymia, a benign condition characterized by spontaneous involuntary contractions of skeletal muscles fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet- discharges of high intraburst frequency (myokymic discharges). Some patients may have isolated myokymia. Defects in KCNQ2 are the cause of epileptic encephalopathy early infantile type 7 (EIEE7). EIEE7 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 20q13.3
Cellular Component: plasma membrane
Molecular Function: ankyrin binding; delayed rectifier potassium channel activity; potassium channel activity; voltage-gated potassium channel activity
Biological Process: nervous system development; potassium ion transport; synaptic transmission
Disease: Epileptic Encephalopathy, Early Infantile, 7; Seizures, Benign Familial Neonatal, 1
Reference #:  O43526 (UniProtKB)
Alt. Names/Synonyms: BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KCNQ2; KQT-like 2; KV7.2; KVEBN1; neuroblastoma-specific potassium channel protein; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; Voltage-gated potassium channel subunit Kv7.2
Gene Symbols: KCNQ2
Molecular weight: 95,848 Da
Basal Isoelectric point: 9.35  Predict pI for various phosphorylation states
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