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Protein Page:
Kv7.2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Kv7.2 Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors. Defects in KCNQ2 are the cause of benign familial neonatal seizures type 1 (BFNS1). A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. Some rare cases manifest an atypical severe phenotype associated with epileptic encephalopathy and psychomotor retardation. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. In some patients, neonatal convulsions are followed later in life by myokymia, a benign condition characterized by spontaneous involuntary contractions of skeletal muscles fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet- discharges of high intraburst frequency (myokymic discharges). Some patients may have isolated myokymia. Defects in KCNQ2 are the cause of epileptic encephalopathy early infantile type 7 (EIEE7). EIEE7 is an autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Chromosomal Location of Human Ortholog: 20q13.3
Cellular Component: plasma membrane
Molecular Function: ankyrin binding; delayed rectifier potassium channel activity; potassium channel activity; voltage-gated potassium channel activity
Biological Process: nervous system development; potassium ion transport; synaptic transmission
Disease: Epileptic Encephalopathy, Early Infantile, 7; Seizures, Benign Familial Neonatal, 1
Reference #:  O43526 (UniProtKB)
Alt. Names/Synonyms: BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KCNQ2; KQT-like 2; KV7.2; KVEBN1; neuroblastoma-specific potassium channel protein; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; Voltage-gated potassium channel subunit Kv7.2
Gene Symbols: KCNQ2
Molecular weight: 95,848 Da
Basal Isoelectric point: 9.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Kv7.2

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S52‑p, T217‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K21 PSGEKKLKVGFVGLD
0 1 K49 IAGSEAPKRGsILSK
1 4 S52‑p SEAPKRGsILSKPRA
2 1 T217‑p RMDRRGGtWKLLGSV
0 2 S229‑p GSVVYAHsKELVTAW
0 1 Y237‑p KELVTAWyIGFLCLI
0 5 S352 RFYATNLSRTDLHST
0 3 Y372‑p RTVTVPMySSQTQTy
0 1 Y379‑p ySSQTQTyGASRLIP
0 1 K398‑ac LELLRNLkSKSGLAF
0 2 S416 PPPEPSPSKGSPCRG
0 1 S438‑p GRSSQKVsLKDRVFs
0 1 S445‑p sLKDRVFsSPRGVAA
0 1 S457 VAAKGKGSPQAQTVR
0 6 S466 QAQTVRRSPSADQSL
0 4 S468 QTVRRSPSADQSLED
0 2 S472 RSPSADQSLEDSPSK
0 3 S476 ADQSLEDSPSKVPKS
0 2 S478 QSLEDSPSKVPKSWS
0 4 S485 SKVPKSWSFGDRSRA
0 5 S507‑p GAASRQNsEEASLPG
0 2 S511 RQNsEEASLPGEDIV
1 0 S539 LTPGLKVSIRAVCVM
1 0 S551 CVMRFLVSKRKFKES
2 0 S558 SKRKFKESLRPyDVM
0 2 Y562‑p FKESLRPyDVMDVIE
0 2 Y571‑p VMDVIEQySAGHLDM
0 5 K602 RGPAITDKDRTKGPA
0 1 K606 ITDKDRTKGPAEAEL
0 1 K635 KQVLSMEKKLDFLVN
0 2 K636 QVLSMEKKLDFLVNI
0 1 Y644‑p LDFLVNIyMQRMGIP
0 2 Y658‑p PPTETEAyFGAKEPE
0 2 Y670 EPEPAPPYHSPEDSR
0 6 S672 EPAPPYHSPEDSREH
0 1 S676 PYHSPEDSREHVDRH
0 1 S692‑p CIVKIVRsssSTGQK
0 1 S693‑p IVKIVRsssSTGQKN
0 1 S694‑p VKIVRsssSTGQKNF
0 1 S738 SPVGDHGSLVRIPPP
0 1 Y755‑p HERSLSAyGGGNRAS
0 1 S787 NLRDSDTSISIPSVD
0 1 S789 RDSDTSISIPSVDHE
0 3 S801 DHEELERSFSGFSIS
0 4 S803 EELERSFSGFSISQS
0 1 S810 SGFSISQSKENLDAL
0 1 Y821‑p LDALNSCyAAVAPCA
0 1 Y833 PCAKVRPYIAEGESD
0 2 S839 PYIAEGESDTDsDLC
0 2 T841 IAEGESDTDsDLCTP
0 3 S843‑p EGESDTDsDLCTPCG
0 3 S855‑p PCGPPPRsAtGEGPF
0 2 T857‑p GPPPRsAtGEGPFGD
  Kv7.2 iso3  
K21 PSGEKKLKVGFVGLD
K49 IAGSEAPKRGSILSK
S52 SEAPKRGSILSKPRA
T217 RMDRRGGTWKLLGSV
S229 GSVVYAHSKELVTAW
Y237 KELVTAWYIGFLCLI
S352 RFYATNLSRTDLHST
Y372‑p RTVTVPMyRLIPPLN
- gap
K388 LELLRNLKSKSGLAF
S406 PPPEPSPSQKVSLKD
S410 PSPSQKVSLKDRVFS
S417 SLKDRVFSSPRGVAA
S429 VAAKGKGSPQAQTVR
S438 QAQTVRRSPSADQSL
S440 QTVRRSPSADQSLED
S444 RSPSADQSLEDSPSK
S448 ADQSLEDSPSKVPKS
S450 QSLEDSPSKVPKSWS
S457 SKVPKSWSFGDRSRA
S479 GAASRQNSEEASLPG
S483 RQNSEEASLPGEDIV
S511‑p LTPGLKVsIRAVCVM
S523 CVMRFLVSKRKFKES
S530 SKRKFKESLRPYDVM
Y534 FKESLRPYDVMDVIE
Y543 VMDVIEQYSAGHLDM
K574 RGPAITDKDRTKGPA
K578 ITDKDRTKGPAEAEL
K607 KQVLSMEKKLDFLVN
K608 QVLSMEKKLDFLVNI
Y616 LDFLVNIYMQRMGIP
Y630 PPTETEAYFGAKEPE
Y642 EPEPAPPYHSPEDSR
S644 EPAPPYHSPEDSREH
S648 PYHSPEDSREHVDRH
S664 CIVKIVRSSSSTGQK
S665 IVKIVRSSSSTGQKN
S666 VKIVRSSSSTGQKNF
S710 SPVGDHGSLVRIPPP
Y727 HERSLSAYGGGNRAS
S759 NLRDSDTSISIPSVD
S761 RDSDTSISIPSVDHE
S773 DHEELERSFSGFSIS
S775 EELERSFSGFSISQS
S782 SGFSISQSKENLDAL
Y793 LDALNSCYAAVAPCA
Y805 PCAKVRPYIAEGESD
S811 PYIAEGESDTDSDLC
T813 IAEGESDTDSDLCTP
S815 EGESDTDSDLCTPCG
S827 PCGPPPRSATGEGPF
T829 GPPPRSATGEGPFGD
  mouse

► Hide Isoforms
 
K21‑ub TSGEKKLkVGFVGLD
K49‑ub IAGSEAPkRGsVLSK
S52‑p SEAPkRGsVLSKPRT
T217 RMDRRGGTWKLLGSV
S229‑p GSVVYAHsKELVTAW
Y237 KELVTAWYIGFLCLI
S352‑p RFYATNLsRTDLHST
Y372 RTVTVPMYRLIPPLN
- gap
K388 LELLRNLKSKSGLTF
S406 PQPEPSPSQKVSLKD
S410 PSPSQKVSLKDRVFS
S417 SLKDRVFSSPRGMAA
S429‑p MAAKGKGsPQAQTVR
S438‑p QAQTVRRsPsADQsL
S440‑p QTVRRsPsADQsLDD
S444‑p RsPsADQsLDDsPsK
S448‑p ADQsLDDsPsKVPKS
S450‑p QsLDDsPsKVPKSWs
S457‑p sKVPKSWsFGDRSRT
S479‑p GAASRQNsEEAsLPG
S483‑p RQNsEEAsLPGEDIV
S512 LTPGLKVSIRAVCVM
S524 CVMRFLVSKRKFKES
S531 SKRKFKESLRPYDVM
Y535 FKESLRPYDVMDVIE
Y544 VMDVIEQYSAGHLDM
K611‑ub RGPTITDkDRTkGPA
K615‑ub ITDkDRTkGPAETEL
K644‑ub KQVLSMEkkLDFLVS
K645‑ub QVLSMEkkLDFLVSI
Y653 LDFLVSIYTQRMGIP
Y667‑p PPAETEAyFGAKEPE
Y679‑p EPEPAPPyHsPEDsR
S681‑p EPAPPyHsPEDsRDH
S685‑p PyHsPEDsRDHADKH
S701 CIIKIVRSTSSTGQR
T702 IIKIVRSTSSTGQRN
S703 IKIVRSTSSTGQRNY
S744 SPVGDHGSLVLRLER
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  Kv7.2 iso3  
K21 TSGEKKLKVGFVGLD
K49 IAGSEAPKRGSVLSK
S52 SEAPKRGSVLSKPRT
T217 RMDRRGGTWKLLGSV
S229 GSVVYAHSKELVTAW
Y237 KELVTAWYIGFLCLI
S352 RFYATNLSRTDLHST
Y372 RTVTVPMYRLIPPLN
- gap
K388 LELLRNLKSKSGLTF
S406‑p PQPEPSPsPRGMAAK
- gap
- gap
S417 MAAKGKGSPQAQTVR
S426 QAQTVRRSPSADQSL
S428 QTVRRSPSADQSLDD
S432 RSPSADQSLDDSPSK
S436 ADQSLDDSPSKVPKS
S438 QSLDDSPSKVPKSWS
S445 SKVPKSWSFGDRSRT
S467 GAASRQNSEEASLPG
S471 RQNSEEASLPGEDIV
S500 LTPGLKVSIRAVCVM
S512 CVMRFLVSKRKFKES
S519 SKRKFKESLRPYDVM
Y523 FKESLRPYDVMDVIE
Y532 VMDVIEQYSAGHLDM
K599 RGPTITDKDRTKGPA
K603 ITDKDRTKGPAETEL
K632 KQVLSMEKKLDFLVS
K633 QVLSMEKKLDFLVSI
Y641 LDFLVSIYTQRMGIP
Y655 PPAETEAYFGAKEPE
Y667 EPEPAPPYHSPEDSR
S669 EPAPPYHSPEDSRDH
S673 PYHSPEDSRDHADKH
S689 CIIKIVRSTSSTGQR
T690 IIKIVRSTSSTGQRN
S691 IKIVRSTSSTGQRNY
S732 SPVGDHGSLVLRLER
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  Kv7.2 iso12  
K21 TSGEKKLKVGFVGLD
K49 IAGSEAPKRGSVLSK
S52 SEAPKRGSVLSKPRT
T217 RMDRRGGTWKLLGSV
S229 GSVVYAHSKELVTAW
Y237 KELVTAWYIGFLCLI
S352 RFYATNLSRTDLHST
Y372 RTVTVPMYSSQTQTY
Y379 YSSQTQTYGASRLIP
K398 LELLRNLKSKSGLTF
S416 PQPEPSPSKGRPCRG
S438 GHSSQKVSLKDRVFS
S445 SLKDRVFSSPRGMAA
S457 MAAKGKGSPQAQTVR
S466 QAQTVRRSPSADQSL
S468 QTVRRSPSADQSLDD
S472 RSPSADQSLDDSPSK
S476 ADQSLDDSPSKVPKS
S478 QSLDDSPSKVPKSWS
S485 SKVPKSWSFGDRSRT
S507 GAASRQNSEEASLPG
S511 RQNSEEASLPGEDIV
S540 LTPGLKVSIRAVCVM
S552 CVMRFLVSKRKFKES
S559 SKRKFKESLRPYDVM
Y563 FKESLRPYDVMDVIE
Y572 VMDVIEQYSAGHLDM
K603 RGPTITDKDRTKGPA
K607 ITDKDRTKGPAETEL
K636 KQVLSMEKKLDFLVS
K637 QVLSMEKKLDFLVSI
Y645 LDFLVSIYTQRMGIP
Y659 PPAETEAYFGAKEPE
Y671 EPEPAPPYHSPEDSR
S673 EPAPPYHSPEDSRDH
S677 PYHSPEDSRDHADKH
S693 CIIKIVRSTSSTGQR
T694 IIKIVRSTSSTGQRN
S695 IKIVRSTSSTGQRNY
S736‑p SPVGDHGsLVRIPPP
Y753 HERSLSAYGGGNRAS
S785‑p ALRDSDTsIsIPSVD
S787‑p RDSDTsIsIPSVDHE
S799‑p DHEELERsFsGFSIS
S801‑p EELERsFsGFSISQs
S808‑p sGFSISQsKENLDAL
Y819 LDALGSCYAAVAPCA
Y831‑p PCAKVRPyIAEGEsD
S837‑p PyIAEGEsDtDsDLC
T839‑p IAEGEsDtDsDLCTP
S841‑p EGEsDtDsDLCTPCG
S853‑p PCGPPPRsATGEGPF
T855 GPPPRsATGEGPFGD
  rat

 
K21 TSGEKKLKVGFVGLD
K49 IAGSEAPKRGSVLSK
S52 SEAPKRGSVLSKPRT
T217‑p RMDRRGGtWKLLGSV
S229 GSVVYAHSKELVTAW
Y237 KELVTAWYIGFLCLI
S352‑p RFYATNLsRTDLHST
I372 RTVTVPMISSQTQTY
Y379 ISSQTQTYGASRLIP
K398 LEMLRNLKSKSGLTF
S416 PQPEPSPSQKVSLKD
S420 PSPSQKVSLKDRVFS
S427 SLKDRVFSSPRGVAA
S439 VAAKGKGSPQAQTVR
S448 QAQTVRRSPSADQSL
S450 QTVRRSPSADQSLDD
S454 RSPSADQSLDDsPSK
S458‑p ADQSLDDsPSKVPKS
S460 QSLDDsPSKVPKSWs
S467‑p SKVPKSWsFGDRSRA
S489‑p GAASRQNsEEAsLPG
S493‑p RQNsEEAsLPGEDIV
S522 LTPGLKVSIRAVCVM
S534‑p CVMRFLVsKRKFKEs
S541‑p sKRKFKEsLRPYDVM
Y545 FKEsLRPYDVMDVIE
Y554 VMDVIEQYSAGHLDM
K585 RGPTITDKDRTKGPA
K589 ITDKDRTKGPAETEL
K618 KQVLSMEKKLDFLVS
K619 QVLSMEKKLDFLVSI
Y627 LDFLVSIYTQRMGIP
Y641 PPAETEAYFGAKEPE
Y653 EPEPAPPYHsPEDSR
S655‑p EPAPPYHsPEDSRDH
S659 PYHsPEDSRDHADKH
S675 CIIKIVRSTSSTGQR
T676 IIKIVRSTSSTGQRK
S677 IKIVRSTSSTGQRKY
S718 SPVGDHGSLVRIPPP
Y735 HERSLSAYSGGNRAS
S767 ALRDSDTSISIPSVD
S769 RDSDTSISIPSVDHE
S781‑p DHEELERsFsGFSIS
S783‑p EELERsFsGFSISQS
S790 sGFSISQSKENLNAL
Y801 LNALASCYAAVAPCA
Y813 PCAKVRPYIAEGESD
S819 PYIAEGESDTDSDLC
T821 IAEGESDTDSDLCTP
S823 EGESDTDSDLCTPCG
S835 PCGPPPRSATGEGPF
T837 GPPPRSATGEGPFGD
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