Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
PRX (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PRX Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition. Defects in PRX are a cause of Dejerine-Sottas syndrome (DSS); also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie- Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome. Belongs to the periaxin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: cell junction; cytoplasm; myelin sheath; nucleus; plasma membrane
Molecular Function: protein binding
Biological Process: axon ensheathment; nerve development
Disease: Charcot-marie-tooth Disease, Demyelinating, Type 4f; Hypertrophic Neuropathy Of Dejerine-sottas
Reference #:  Q9BXM0 (UniProtKB)
Alt. Names/Synonyms: CMT4F; KIAA1620; Periaxin; PRAX; PRX
Gene Symbols: PRX
Molecular weight: 154,905 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
Select Structure to View Below

PRX

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S7 _MEARSRSAEELRRA
0 1 T102‑p CLKRTVPtGDLALRP
0 1 T111‑p DLALRPGtVsGYEIK
0 1 S113‑p ALRPGtVsGYEIKGP
0 1 S133 KLNIQSLSPVKKKKM
0 1 P142 VKKKKMVPGALGVPA
0 1 G243 LVGPRLPGAEVGVPQ
0 1 K370 PRFGARAKEVAEAKV
0 1 K376 AKEVAEAKVAKVSPE
0 1 S381 EAKVAKVSPEARVKG
0 1 G798 QAEGMEFGFKMPKMt
0 2 T805‑p GFKMPKMtMPKLGRA
0 1 K819 AESPSRGKPGEAGAE
0 1 R881 AKMGKGERVEGPEVA
0 9 S900‑p EVGFRVPsVEIVTPQ
0 1 S965‑p KVSKFAIsLPKARVG
0 1 K1015 EVAGADLKFKGPRFA
0 1 T1033 FGVRGRDTEAAELVP
0 1 S1065 MPKLKMPSFGLARGK
0 1 K1072 SFGLARGKEAEVQGD
0 3 S1082 EVQGDRASPGEKAES
0 3 S1119‑p AEGAVAVsGMQLSGL
0 1 S1328‑p EEGEKAKsPKLRLPR
0 1 T1345 FSQSEMVTGEGSPSP
0 1 S1349 EMVTGEGSPSPEEEE
0 1 S1351 VTGEGSPSPEEEEEE
0 1 S1363 EEEEEEGSGEGASGR
0 1 K1400 QEGDAAPKsPVREKs
0 4 S1401‑p EGDAAPKsPVREKsP
0 1 K1406 PKsPVREKsPKFRFP
0 5 S1407‑p KsPVREKsPKFRFPR
0 54 S1439‑p GLRVRLPsVGFSEtG
0 1 T1445‑p PsVGFSEtGAPGPAR
  PRX iso2  
S7 _MEARSRSAEELRRA
T102 CLKRTVPTGDLALRP
T111 DLALRPGTVSGYEIK
S113 ALRPGTVSGYEIKGP
S132 AKLVRVLSPAPALDC
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  PRX iso3  
- gap
- gap
- gap
- gap
- gap
P3 _____MVPGALGVPA
G104 LVGPRLPGAEVGVPQ
K231 PRFGARAKEVAEAKV
K237 AKEVAEAKVAKVSPE
S242 EAKVAKVSPEARVKG
G659 QAEGMEFGFKMPKMT
T666 GFKMPKMTMPKLGRA
K680 AESPSRGKPGEAGAE
R742 AKMGKGERVEGPEVA
S761 EVGFRVPSVEIVTPQ
S826 KVSKFAISLPKARVG
K876 EVAGADLKFKGPRFA
T894 FGVRGRDTEAAELVP
S926 MPKLKMPSFGLARGK
K933 SFGLARGKEAEVQGD
S943 EVQGDRASPGEKAES
S980 AEGAVAVSGMQLSGL
S1189 EEGEKAKSPKLRLPR
T1206 FSQSEMVTGEGSPSP
S1210 EMVTGEGSPSPEEEE
S1212 VTGEGSPSPEEEEEE
S1224 EEEEEEGSGEGASGR
K1261 QEGDAAPKSPVREKS
S1262 EGDAAPKSPVREKSP
K1267 PKSPVREKSPKFRFP
S1268 KSPVREKSPKFRFPR
S1300 GLRVRLPSVGFSETG
T1306 PSVGFSETGAPGPAR
  mouse

 
S7‑p _MEARSRsAEELRRA
T102 CLKRTVPTGDLALRP
T111 DLALRPGTVSGYEMK
S113 ALRPGTVSGYEMKGP
A133 KLNIQSLAPVKKKKM
T142‑p VKKKKMVtGALGTPA
S243 LVGPRLPSAEVGVPQ
K370 PRFGIRGKEATEAKV
K376 GKEATEAKVVKGsPE
S381‑p EAKVVKGsPEAKAKG
S750‑p QAKGTEFsFKLPKMT
T757 sFKLPKMTMPKLGKV
K766 PKLGKVGKPGEASIE
K829 AVPGKVEKPEGPRVA
S848‑p EVGFRVPsVEIVTPQ
S913 KVSKFTISLPKARAG
K961 KVEVADSKPKSSRFA
S979‑p FGVKGRDsEADVLVA
S1011‑p MPKLKMPsFGLSRGK
K1018 sFGLSRGKEAETQDG
S1028‑p ETQDGRVsPGEKLEA
S1060 QETEKVTSGVKPSGL
S1262 EVGEKVKSPKLRLPR
S1279‑p FSQSESVsGEGsPsP
S1283‑p ESVsGEGsPsPEEEE
S1285‑p VsGEGsPsPEEEEEG
S1293‑p PEEEEEGsGEGASSR
K1330 QEGDATSKsPVGEKs
S1331‑p EGDATSKsPVGEKsP
K1336 SKsPVGEKsPKFRFP
S1337‑p KsPVGEKsPKFRFPR
S1369‑p GFRVRLPsVGFSETA
T1375 PsVGFSETAVPGSTR
  rat

 
S7‑p _MEARSRsAEELRRA
T102 CLKRTVPTGDLALRP
T111 DLALRPGTVSGYEMK
S113 ALRPGTVSGYEMKGP
S133‑p KLNIQSLsPVKKKKM
I142 VKKKKMVIGTLGTPA
S243‑p LVGPRLPsAEVGVPK
K370‑ac PRFGVRGkEATEAkV
K376‑ac GkEATEAkVVKGSPE
S381 EAkVVKGSPEAKAKG
S740 QAEKTEFSFKLPKMT
T747 SFKLPKMTVPKLGKV
K756‑ac PKLGKVTkPGEAGIE
K819‑ac AVSGKVEkPEGPRVA
S838‑p EAGFRVPsVEIVNPQ
S903 KVSKFAISLPRARAG
K953‑ac EVAGAESkPKGSRFA
S971 FGAKGRDSEADVLVA
S1003 MPKLKMPSFGLSRGk
K1010‑ac SFGLSRGkEAEIQDG
S1020‑p EIQDGRVsPGEKLEA
S1052 QETEKVTSGVKPSGL
S1254 ETGEKVKSPKLRLPR
S1271 FSQSESASGEGSPSP
S1275 ESASGEGSPSPEEEE
S1277 ASGEGSPSPEEEEEG
S1285 PEEEEEGSGEGASGR
K1322‑ub QEGDAASksPVGEks
S1323‑p EGDAASksPVGEksP
K1328‑ub SksPVGEksPKFRFP
S1329‑p ksPVGEksPKFRFPR
S1361‑p GFRVRLPsVGFSETA
T1367 PsVGFSETAAPGSAR
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.