a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. Note: This description may include information from UniProtKB.
Cellular Component: cilium; extracellular region; mitochondrion; neuron projection; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane
Molecular Function: DNA binding; drug binding; enzyme binding; estrogen receptor activity; estrogen response element binding; ligand-dependent nuclear receptor activity; peroxisome proliferator activated receptor binding; protein binding; receptor antagonist activity; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; zinc ion binding
Biological Process: amygdala development; behavioral fear response; cell-cell signaling; cerebellum development; estrogen receptor signaling pathway; hypothalamus development; learning and/or memory; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; ovarian follicle development; positive regulation of apoptosis; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of vasodilation; prostate gland development; regulation of neuron apoptosis; regulation of transcription, DNA-dependent; response to activity; response to ethanol; response to genistein; response to insecticide; response to nutrient levels; response to testosterone stimulus; response to water deprivation; Sertoli cell development; Sertoli cell proliferation; signal transduction; transcription initiation from RNA polymerase II promoter
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.