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EEF2
a member of the GTP-binding translation elongation factor family. An essential factor for protein synthesis. Promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by eEF2 kinase phosphorylation. eEF2 kinase is normally dependent on Ca2+ ions and calmodulin. eEF2 kinase can also be activated by PKA in response to elevated cAMP levels, which are generally increased in stress- or starvation-related conditions. A variety of treatments known to raise intracellular Ca2+ or cAMP levels have been shown to result in increased phosphorylation of eEF2, and thus to inhibit peptide-chain elongation. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation elongation |
| Chromosomal Location of Human Ortholog: 19p13.3 |
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Cellular Component: cytoplasm; cytosol; extracellular matrix; extracellular region; membrane; nucleus; plasma membrane; ribonucleoprotein complex
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Molecular Function: cadherin binding; protein binding; protein kinase binding; RNA binding
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Biological Process: neutrophil degranulation; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; positive regulation of translation; protein amino acid methylation; translational elongation
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Disease: Spinocerebellar Ataxia 26
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Reference #:
P13639
(UniProtKB)
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Alt. Names/Synonyms: EEF-2; EEF2; EF-2; EF2; Elongation factor 2; eukaryotic translation elongation factor 2; polypeptidyl-tRNA translocase
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Gene Symbols: EEF2
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Molecular weight:
95,338 Da
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Basal Isoelectric point:
6.41
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Translational Control
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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