Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
PIK4CB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK4CB a member of the PI3/PI4 kinase family. Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex. May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 2.7.1.67; Kinase, lipid
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: cytoplasm; cytosol; endosome; Golgi membrane
Molecular Function: 1-phosphatidylinositol 4-kinase activity; protein binding
Biological Process: phosphatidylinositol biosynthetic process; receptor-mediated endocytosis; signal transduction
Reference #:  Q9UBF8 (UniProtKB)
Alt. Names/Synonyms: NPIK; Phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta; phosphatidylinositol 4-kinase, wortmannin-sensitive; PI4K-beta; PI4K92; PI4KB; PI4Kbeta; PI4KIIIBETA; PIK4CB; PtdIns 4-kinase beta; type III phosphatidylinositol 4-kinase beta
Gene Symbols: PI4KB
Molecular weight: 91,379 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Select Structure to View Below

PIK4CB

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Sites Implicated In
molecular association, regulation: S294‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S69 LHGGVAVSSRGTPLE
0 1 S110 EMGAAVASGTAKGAR
0 1 Y147‑p DISMAISyLYNSKEP
0 1 S205‑p IVHRCRQsINFsLQC
0 1 S209‑p CRQsINFsLQCALLL
0 1 S242 KLRKLILSDELKPAH
0 3 S256‑p HRKRELPsLsPAPDt
0 15 S258‑p KRELPsLsPAPDtGL
0 5 T263‑p sLsPAPDtGLsPsKR
1 12 S266‑p PAPDtGLsPsKRTHQ
0 1 S268‑p PDtGLsPsKRTHQRs
0 11 S275‑p sKRTHQRsKsDAtAS
1 31 S277‑p RTHQRsKsDAtASIS
0 4 T280‑p QRsKsDAtASISLsS
0 2 S282 sKsDAtASISLsSNL
0 1 S284 sDAtASISLsSNLkR
0 1 S286‑p AtASISLsSNLkRTA
0 1 K290‑m2 ISLsSNLkRTAsNPK
0 4 T292 LsSNLkRTAsNPKVE
5 37 S294‑p SNLkRTAsNPKVENE
0 1 T341‑p AIGKRLAtLPTKEQK
0 1 T349‑p LPTKEQKtQRLISEL
0 14 S425‑p IPENRIRstRsVENL
0 2 T426‑p PENRIRstRsVENLP
0 70 S428‑p NRIRstRsVENLPEC
0 1 T438 NLPECGITHEQRAGS
0 1 D488‑ca NISQFSVdSITSQES
1 53 S511‑p GDIRRRLsEQLAHtP
0 10 T517‑p LsEQLAHtPtAFKRD
1 2 T519‑p EQLAHtPtAFKRDPE
0 2 K742‑ac QGLIAARkHMDKVVQ
0 4 Y805‑p RSITTKLyDGFQyLT
0 1 Y810‑p KLyDGFQyLTNGIM_
  PIK4CB iso2  
S69 LHGGVAVSSRGTPLE
S110 EMGAAVASGTAKGAR
Y147 DISMAISYLYNSKEP
S205 IVHRCRQSINFSLQC
S209 CRQSINFSLQCALLL
S242 KLRKLILSDELKPAH
S256 HRKRELPSLsPAPDt
S258‑p KRELPSLsPAPDtGL
T263‑p SLsPAPDtGLsPSKR
S266‑p PAPDtGLsPSKRTHQ
S268 PDtGLsPSKRTHQRS
S275 SKRTHQRSKsDATAS
S277‑p RTHQRSKsDATASIS
T280 QRSKsDATASISLSS
S282 SKsDATASISLSSNL
S284 sDATASISLSSNLKR
S286 ATASISLSSNLKRtA
K290 ISLSSNLKRtAsNPK
T292‑p LSSNLKRtAsNPKVE
S294‑p SNLKRtAsNPKVENE
T326 AIGKRLATLPTKEQK
T334 LPTKEQKTQRLISEL
S410 IPENRIRSTRSVENL
T411 PENRIRSTRSVENLP
S413 NRIRSTRSVENLPEC
T423‑p NLPECGItHEQRAGS
D473 NISQFSVDSITSQES
S496‑p GDIRRRLsEQLAHTP
T502 LsEQLAHTPtAFKRD
T504‑p EQLAHTPtAFKRDPE
K727‑ac QGLIAARkHMDKVVQ
Y790 RSITTKLYDGFQYLT
Y795 KLYDGFQYLTNGIM_
  mouse

► Hide Isoforms
 
S69‑p LHGGVAIsSKGTPLE
S110‑p EMGAGVAsGTAKGAR
Y147 DISMAISYLYNSKEP
S205 IVHRCRQSINFSLQC
S209 CRQSINFSLQCALLL
S242‑p KLRKLILsDELKPAH
T256 HRKRELPTLsPAPDT
S258‑p KRELPTLsPAPDTGL
T263 TLsPAPDTGLsPSKR
S266‑p PAPDTGLsPSKRTHQ
S268 PDTGLsPSKRTHQRs
S275‑p SKRTHQRsKsDAtAs
S277‑p RTHQRsKsDAtAsIs
T280‑p QRsKsDAtAsIsLSS
S282‑p sKsDAtAsIsLSSNL
S284‑p sDAtAsIsLSSNLKR
S286 AtAsIsLSSNLKRtA
K290 IsLSSNLKRtAsNPK
T292‑p LSSNLKRtAsNPKVE
S294‑p SNLKRtAsNPKVENE
T341 AIGKRLATLPTKEQK
T349 LPTKEQKTQRLISEL
S425‑p IPENRIRsTRsVENL
T426 PENRIRsTRsVENLP
S428‑p NRIRsTRsVENLPEC
T438 NLPECGITHEQRAGS
D488 NISQFSVDSITSQES
S511‑p GDIRRRLsEQLAHtP
T517‑p LsEQLAHtPTAFKRD
T519 EQLAHtPTAFKRDPE
K742 QGLIAARKHMDKVVQ
Y805 RSITTKLYDGFQYLT
Y810 KLYDGFQYLTNGIM_
  PIK4CB iso2  
S69 LHGGVAISSKGTPLE
S110 EMGAGVASGTAKGAR
Y147 DISMAISYLYNSKEP
S205 IVHRCRQSINFSLQC
S209 CRQSINFSLQCALLL
S242 KLRKLILSDELKPAH
T256 HRKRELPTLSPAPDT
S258 KRELPTLSPAPDTGL
T263 TLSPAPDTGLSPSKR
S266 PAPDTGLSPSKRTHQ
S268 PDTGLSPSKRTHQRS
S275 SKRTHQRSKSDATAS
S277 RTHQRSKSDATASIS
T280 QRSKSDATASISLSS
S282 SKSDATASISLSSNL
S284 SDATASISLSSNLKR
S286 ATASISLSSNLKRtA
K290 ISLSSNLKRtAsNPK
T292‑p LSSNLKRtAsNPKVE
S294‑p SNLKRtAsNPKVENE
T326 AIGKRLATLPTKEQK
T334 LPTKEQKTQRLISEL
S410 IPENRIRSTRSVENL
T411 PENRIRSTRSVENLP
S413 NRIRSTRSVENLPEC
T423 NLPECGITHEQRAGS
D473 NISQFSVDSITSQES
S496 GDIRRRLSEQLAHTP
T502 LSEQLAHTPTAFKRD
T504 EQLAHTPTAFKRDPE
K727 QGLIAARKHMDKVVQ
Y790 RSITTKLYDGFQYLT
Y795 KLYDGFQYLTNGIM_
  rat

► Hide Isoforms
 
S69 LHGGVAISSKGSPLE
S110 EMEPGVVSGTAKGTR
Y147 DISMAISYLYNSKEP
S205 IVHRCRQSINFSLQC
S209 CRQSINFSLQCALLL
S242 KLRKLILSDELKPAH
T256 HRKRELPTLSPAPDT
S258 KRELPTLSPAPDTGL
T263 TLSPAPDTGLSPSKR
S266 PAPDTGLSPSKRTHQ
S268 PDTGLSPSKRTHQRS
S275 SKRTHQRSKSDATAS
S277 RTHQRSKSDATASIS
T280 QRSKSDATASISLSS
S282 SKSDATASISLSSNL
S284 SDATASISLSSNLKR
S286 ATASISLSSNLKRTA
K290 ISLSSNLKRTASNPK
T292 LSSNLKRTASNPKVE
S294 SNLKRTASNPKVENE
T341 AIGKRLATLPTKEQK
T349 LPTKEQKTQRLISEL
S425‑p IPENRIRsTRsVENL
T426 PENRIRsTRsVENLP
S428‑p NRIRsTRsVENLPEC
T438 NLPECGITHEQRAGS
D488 NISQFSVDSITSQES
S511‑p GDIRRRLsEQLAHTP
T517 LsEQLAHTPTAFKRD
T519 EQLAHTPTAFKRDPE
K742 QGLIAARKHMDKVVQ
Y805 RSITTKLYDGFQYLT
Y810 KLYDGFQYLTNGIM_
  PIK4CB iso5  
S69 LHGGVAISSKGSPLE
S110 EMEPGVVSGTAKGTR
Y147 DISMAISYLYNSKEP
S205 IVHRCRQSINFSLQC
S209 CRQSINFSLQCALLL
S242 KLRKLILSDELKPAH
T256 HRKRELPTLSPAPDT
S258 KRELPTLSPAPDTGL
T263 TLSPAPDTGLSPSKR
S266 PAPDTGLSPSKRTHQ
S268 PDTGLSPSKRTHQRS
S275 SKRTHQRSKSDATAS
S277 RTHQRSKSDATASIS
T280 QRSKSDATASISLSS
S282 SKSDATASISLSSNL
S284 SDATASISLSSNLKR
S286 ATASISLSSNLKRTA
K290 ISLSSNLKRTAsNPK
T292 LSSNLKRTAsNPKVE
S294‑p SNLKRTAsNPKVENE
T326 AIGKRLATLPTKEQK
T334 LPTKEQKTQRLISEL
S410 IPENRIRSTRSVENL
T411 PENRIRSTRSVENLP
S413 NRIRSTRSVENLPEC
T423 NLPECGITHEQRAGS
D473 NISQFSVDSITSQES
S496 GDIRRRLSEQLAHTP
T502 LSEQLAHTPTAFKRD
T504 EQLAHTPTAFKRDPE
K727 QGLIAARKHMDKVVQ
Y790 RSITTKLYDGFQYLT
Y795 KLYDGFQYLTNGIM_
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.