Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
HLAC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HLAC Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum; Golgi apparatus; Golgi membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane
Molecular Function: antigen binding; peptide antigen binding
Biological Process: antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; regulation of immune response
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Psoriasis 1, Susceptibility To
Reference #:  P30501 (UniProtKB)
Alt. Names/Synonyms: 1C02; class I MHC antigen HLA-B heavy chain; D6S204; FLJ27082; HLA class I antigen; HLA class I heavy chain; HLA class I histocompatibility antigen, C alpha chain; HLA class I histocompatibility antigen, Cw-1 alpha chain; HLA class I histocompatibility antigen, Cw-12 alpha chain; HLA class I histocompatibility antigen, Cw-14 alpha chain; HLA class I histocompatibility antigen, Cw-16 alpha chain; HLA class I histocompatibility antigen, Cw-17 alpha chain; HLA class I histocompatibility antigen, Cw-2 alpha chain; HLA class I histocompatibility antigen, Cw-4 alpha chain; HLA class I histocompatibility antigen, Cw-6 alpha chain; HLA class I histocompatibility antigen, Cw-7 alpha chain; HLA class I histocompatibility antigen, Cw-8 alpha chain; HLA-C; HLA-C (Cw*1201); HLA-Cw; HLA-Cw*050x; HLA-Cw12; HLA-JY3; HLAC; HLC-C; human leukocyte antigen-C alpha chain; leucocyte antigen C; leucocyte antigen Cw; leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; major histocompatibility complex, class I, C; MHC class I antigen Cw*1; MHC class I antigen Cw*12; MHC class I antigen Cw*14; MHC class I antigen Cw*16; MHC class I antigen Cw*17; MHC class I antigen Cw*2; MHC class I antigen Cw*4; MHC class I antigen Cw*6; MHC class I antigen Cw*7; MHC class I antigen Cw*8; MHC class I antigen heavy chain HLA-C; MHC class I antigen HLA-C; MHC class I HLA-C; MHC class I HLA-Cw*0803; MHC class I protein HLA-C heavy chain; PSORS1
Gene Symbols: HLA-C
Molecular weight: 41,095 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Select Structure to View Below

HLAC

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T20 LSGALALTETWACSH
0 1 S28 ETWACSHSMRYFYTA
0 1 Y51‑p PHFIAVGyVDDTQFV
0 1 T55 AVGyVDDTQFVRFDS
0 2 Y83‑p VEQEGPEyWDRETQk
0 1 K90‑ub yWDRETQkYNRQAQT
0 1 N92 DRETQkYNRQAQTDR
0 1 T97 kYNRQAQTDRVNLRK
0 10 K145‑ub DQSAYDGkDyIALNE
0 2 Y147‑p SAYDGkDyIALNEDL
0 1 S156 ALNEDLRSWTAADTA
0 1 T162 RSWTAADTAAQITQR
0 4 K170‑ub AAQITQRkWEAAREA
0 1 Y183 EAEEWRAYLEGECVE
0 1 W191 LEGECVEWLRRYLEN
0 26 K200 RRYLENGKEKLQRAE
0 8 K202 YLENGKEKLQRAEHP
0 5 K210‑ub LQRAEHPkTHVTHHP
0 1 S219‑p HVTHHPVsDHEATLR
0 10 K267‑ub AGDGTFQkWAAVVVP
0 1 A270 GTFQkWAAVVVPsGE
0 1 S275‑p WAAVVVPsGEEQRYT
0 14 K341 RRKSSGGKGGSCSQA
0 1 - gap
0 2 - gap
0 41 - gap
0 9 - gap
0 10 - gap
0 1 S344 SSGGKGGSCSQAASS
0 2 S350 GSCSQAASSNSAQGs
0 3 S351 SCSQAASSNSAQGsD
0 3 S353 SQAASSNSAQGsDES
0 27 S357‑p SSNSAQGsDESLIAS
0 33 S360 SAQGsDESLIASKA_
0 48 K365 DESLIASKA______
0 6 - gap
  HLAC iso2  
T20 LSGALALTETWACSH
S28 ETWACSHSMKYFFTS
Y51‑p PRFISVGyVDDTQFV
T55 SVGyVDDTQFVRFDS
Y83‑p VEQEGPEyWDRETQK
K90 yWDRETQKYNRQAQT
N92 DRETQKYNRQAQTDR
T97 KYNRQAQTDRVSLRN
K145‑ub DQYAYDGkDYIALNE
Y147 YAYDGkDYIALNEDL
S156 ALNEDLRSWTAADTA
T162 RSWTAADTAAQITQR
K170 AAQITQRKWEAAREA
Y183 EAEERRAYLEGTCVE
W191 LEGTCVEWLRRYLEN
K200 RRYLENGKESLQRAE
S202 YLENGKESLQRAEHP
K210 LQRAEHPKTHVTHHP
S219 HVTHHPVSDHEATLR
K267 AGDGTFQKWAAVMVP
A270 GTFQKWAAVMVPSGE
S275 WAAVMVPSGEEQRYT
K341 RRKSSGGKGGSCSQA
- gap
- gap
- gap
- gap
- gap
S344 SSGGKGGSCSQAASS
S350 GSCSQAASSNSAQGS
S351 SCSQAASSNSAQGSD
S353 SQAASSNSAQGSDES
S357 SSNSAQGSDESLIAS
S360 SAQGSDESLIASKA_
K365 DESLIASKA______
- gap
  HLAC iso5  
T20 LSGALALTETWACSH
S28 ETWACSHSMRYFYTA
Y51 PRFIAVGYVDDTQFV
T55 AVGYVDDTQFVQFDS
Y83‑p VEQEGPEyWDRETQK
K90 yWDRETQKYKRQAQT
K92 DRETQKYKRQAQTDR
T97 KYKRQAQTDRVNLRK
K145‑ub NQFAYDGkDYIALNE
Y147 FAYDGkDYIALNEDL
S156 ALNEDLRSWTAADkA
K162‑ub RSWTAADkAAQITQR
K170 AAQITQRKWEAAREA
Y183 EAEQRRAYLEGTCVE
W191 LEGTCVEWLRRYLEN
K200 RRYLENGKKTLQRAE
T202 YLENGKKTLQRAEHP
K210‑ub LQRAEHPkTHVTHHP
S219 HVTHHPVSDHEATLR
K267‑ub AGDGTFQkWAAVVVP
A270 GTFQkWAAVVVPSGE
S275 WAAVVVPSGEEQRYT
K341‑ub RRKSSGGkGGsCSQA
- gap
- gap
- gap
- gap
- gap
S344‑p SSGGkGGsCSQAAss
S350‑p GsCSQAAssNsAQGs
S351‑p sCSQAAssNsAQGsD
S353‑p SQAAssNsAQGsDEs
S357‑p ssNsAQGsDEsLIAC
S360‑p sAQGsDEsLIACkA_
K365‑ub DEsLIACkA______
- gap
  HLAC iso7  
T20 LSGGLALTETWACSH
S28 ETWACSHSMRYFDTA
Y51‑p PRFISVGyVDDTQFV
T55 SVGyVDDTQFVRFDS
Y83‑p VEQEGPEyWDRETQK
K90 yWDRETQKYKRQAQA
K92 DRETQKYKRQAQADR
A97 KYKRQAQADRVSLRN
K145 DQSAYDGKDYIALNE
Y147 SAYDGKDYIALNEDL
S156 ALNEDLRSWTAADTA
T162 RSWTAADTAAQITQR
K170 AAQITQRKLEAARAA
Y183‑p AAEQLRAyLEGTCVE
W191 LEGTCVEWLRRYLEN
K200‑ub RRYLENGkEtLQRAE
T202‑p YLENGkEtLQRAEPP
K210 LQRAEPPKTHVTHHP
S219 HVTHHPLSDHEATLR
K267‑ub AGDGTFQkWAAVVVP
A270 GTFQkWAAVVVPSGQ
S275 WAAVVVPSGQEQRYT
K341‑ub RRKSSGGkGGSCSQA
- gap
- gap
- gap
- gap
- gap
S344 SSGGkGGSCSQAACS
- gap
S351 SCSQAACSNSAQGsD
S353 SQAACSNSAQGsDEs
S357‑p CSNSAQGsDEsLITC
S360‑p SAQGsDEsLITCkA_
K365‑ub DEsLITCkA______
- gap
  HLAC iso14  
T20 LSGALALTETWACSH
S28 ETWACSHSMRYFYTA
Y51 PRFIAVGYVDDTQFV
T55 AVGYVDDTQFVQFDS
Y83‑p VEQEGPEyWDRETQK
K90 yWDRETQKYKRQAQT
K92 DRETQKYKRQAQTDR
T97 KYKRQAQTDRVNLRK
K145 NQFAYDGKDYIALNE
Y147 FAYDGKDYIALNEDL
S156 ALNEDLRSWTAADKA
K162 RSWTAADKAAQITQR
K170 AAQITQRKWEAAREA
Y183 EAEQRRAYLEGTCVE
W191 LEGTCVEWLRRYLEN
K200 RRYLENGKKTLQRAE
T202 YLENGKKTLQRAEHP
K210 LQRAEHPKTHVTHHP
S219 HVTHHPVSDHEATLR
K267 AGDGTFQKWAAVVVP
A270 GTFQKWAAVVVPSGE
S275 WAAVVVPSGEEQRYT
- gap
S345‑p SGREGVRsGVWPAtV
T351‑p RsGVWPAtVPRALMS
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  HLAC iso15  
- gap
S3 _____SHSMRYFYTA
Y26 PHFIAVGYVDDTQFV
T30 AVGYVDDTQFVRFDS
Y58‑p VEQEGPEyWDRETQN
N65 yWDRETQNYkRQAQT
K67‑ub DRETQNYkRQAQTDR
T72 NYkRQAQTDRVNLRK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  HLAC iso20  
T20 LSGGLALTETWACSH
S28 ETWACSHSMRYFDTA
Y51‑p PRFISVGyVDDTQFV
T55 SVGyVDDTQFVRFDS
Y83‑p VEQEGPEyWDRETQK
K90 yWDRETQKYKRQAQA
K92 DRETQKYKRQAQADR
A97 KYKRQAQADRVSLRN
K145‑ub DQFAYDGkDYIALNE
Y147 FAYDGkDYIALNEDL
S156 ALNEDLRSWTAADTA
T162 RSWTAADTAAQITQR
K170 AAQITQRKLEAARAA
Y183 AAEQDRAYLEGTCVE
W191 LEGTCVEWLRRYLEN
K200 RRYLENGKKTLQRAE
T202 YLENGKKTLQRAEPP
K210 LQRAEPPKTHVTHHP
S219 HVTHHPLSDHEATLR
K267‑ub AGDGTFQkWAAVVVP
A270 GTFQkWAAVVVPSGQ
S275 WAAVVVPSGQEQRYT
K341 RRKSSGGKGGSCSQA
- gap
- gap
- gap
- gap
- gap
S344 SSGGKGGSCSQAACS
C350 GSCSQAACSNSAQGs
S351 SCSQAACSNSAQGsD
S353 SQAACSNSAQGsDEs
S357‑p CSNSAQGsDEsLITC
S360‑p SAQGsDEsLITCkA_
K365‑ub DEsLITCkA______
- gap
  mouse

► Hide Isoforms
 
A20 LAAALAPAQTRAGPH
S28 QTRAGPHSLRYFETV
Y51 PRFISVGYVDNTEFV
T55 SVGYVDNTEFVRFDS
Y83 MEQEGPEYWERETQI
I90 YWERETQIAKGNEQS
K92 ERETQIAKGNEQSFR
S97 IAKGNEQSFRVDLRT
C145 EQFAYDGCDYIALNE
Y147 FAYDGCDYIALNEDL
T156 ALNEDLKTWTAADMA
M162 KTWTAADMAALITKH
K170 AALITKHKWEQAGAA
Y183 AAERDRAYLEGTCVE
W191 LEGTCVEWLRRYLEL
N200 RRYLELGNATLLHTD
T202 YLELGNATLLHTDSP
K210 LLHTDSPKAHVTHHP
S219 HVTHHPRSKVEVTLR
K267‑ub AGDGTFQkWASVVVP
S270 GTFQkWASVVVPLGK
L275 WASVVVPLGKEQNYT
K340 MRRNTGGKGGDYTLT
- gap
- gap
Y344 TGGKGGDYTLTPGSQ
S350 DYTLTPGSQSsEMsL
S352 TLTPGSQSsEMsLPD
- gap
- gap
- gap
- gap
S353‑p LTPGSQSsEMsLPDC
S356‑p GSQSsEMsLPDCKA_
K361 EMsLPDCKA______
- gap
  HLAC iso7  
T17 LAAALAPTQTRAGPH
S25 QTRAGPHSLRYFETA
Y48 PRYMEVGYVDDTEFV
T52 EVGYVDDTEFVRFDS
Y80 MEQVEPEYWEEQTQI
I87 YWEEQTQIAKGNEQR
K89 EEQTQIAKGNEQRsR
S95‑p AKGNEQRsRVNLRTA
R142 EQVAYDGRDYIALNE
Y144 VAYDGRDYIALNEDL
T153 ALNEDLKTWTAADMA
M159 KTWTAADMAALITKH
K167 AALITKHKWEQAGAA
Y180 AAERRRAYLEGTCVE
W188 LEGTCVEWLRRYLEL
N197 RRYLELGNATLLRTD
T199 YLELGNATLLRTDSP
K207 LLRTDSPKAHVTHHS
P216 HVTHHSRPEDKATLR
K264 AGDGTFQKWASVVVP
S267 GTFQKWASVVVPLGK
L272 WASVVVPLGKEQYYT
K337‑ub RRRNTGGkGGDyALA
- gap
- gap
Y341‑p TGGkGGDyALAPGsQ
S347‑p DyALAPGsQtsDLsL
T349‑p ALAPGsQtsDLsLPD
- gap
- gap
- gap
- gap
S350‑p LAPGsQtsDLsLPDC
S353‑p GsQtsDLsLPDCKVM
K358 DLsLPDCKVMVHNPH
S366‑p VMVHNPHsLA_____
  HLAC iso21  
T17 LAAALAPTQTRAGPH
S25 QTRAGPHSLRYFVTA
Y48 PRYMEVGYVDDTEFV
T52 EVGYVDDTEFVRFDS
Y80 MEQEGPEYWERETQK
K87 YWERETQKAKGNEQS
K89 ERETQKAKGNEQSFR
S94 KAKGNEQSFRVDLRT
C142 QQYAYDGCDYIALNE
Y144 YAYDGCDYIALNEDL
T153 ALNEDLKTWTAADMA
M159 KTWTAADMAALITKH
K167 AALITKHKWEQAGEA
Y180 EAERLRAYLEGTCVE
W188 LEGTCVEWLRRYLKN
N197 RRYLKNGNAtLLRTD
T199‑p YLKNGNAtLLRTDSP
K207 LLRTDSPKAHVTHHS
P216 HVTHHSRPEDKVTLR
K264 AGDGTFQKWASVVVP
S267 GTFQKWASVVVPLGK
L272 WASVVVPLGKEQYYT
K338‑ub RRRNTGGkGGDyALA
- gap
- gap
Y342‑p TGGkGGDyALAPGsQ
S348‑p DyALAPGsQtsDLsL
T350‑p ALAPGsQtsDLsLPD
- gap
- gap
- gap
- gap
S351‑p LAPGsQtsDLsLPDC
S354‑p GsQtsDLsLPDCkVM
K359‑ub DLsLPDCkVMVHDPH
S367‑p VMVHDPHsLA_____
  HLAC iso22  
T17 LAAALAPTQTRAGPH
S25 QTRAGPHSLRYFVTA
Y48 PRFIAVGYVDDTQFV
T52 AVGYVDDTQFVRFDS
Y80 MEQEGPEYWEEQTQR
R87 YWEEQTQRAKSDEQW
K89 EEQTQRAKSDEQWFR
W94 RAKSDEQWFRVSLRT
R142 QQFAYDGRDYIALNE
Y144 FAYDGRDYIALNEDL
T153 ALNEDLKTWTAADTA
T159 KTWTAADTAALITRR
K167 AALITRRKWEQAGDA
Y180 DAEYYRAYLEGECVE
W188 LEGECVEWLRRYLEL
N197 RRYLELGNETLLRTD
T199 YLELGNETLLRTDSP
K207 LLRTDSPKAHVTYHP
S216 HVTYHPRSQVDVTLR
K264 AGDGTFQKWAAVVVP
A267 GTFQKWAAVVVPLGK
L272 WAAVVVPLGKEQNYT
K337‑ub MRRNTGGkGVNyALA
- gap
- gap
Y341‑p TGGkGVNyALAPGsQ
S347‑p NyALAPGsQtsDLsL
T349‑p ALAPGsQtsDLsLPD
- gap
- gap
- gap
- gap
S350‑p LAPGsQtsDLsLPDG
S353‑p GsQtsDLsLPDGKVM
K358 DLsLPDGKVMVHDPH
S366‑p VMVHDPHsLA_____
  HLAC iso23  
T20 LAAALGPTQTRAGSH
S28 QTRAGSHSLRYFVTA
Y51 PRYMEVGYVDNTEFV
T55 EVGYVDNTEFVRFDS
Y83 IEQEGPEYWERETRR
R90 YWERETRRAKGNEQS
K92 ERETRRAKGNEQSFR
S97 RAKGNEQSFRVDLRT
C145 WQFAYDGCDYIALNE
Y147 FAYDGCDYIALNEDL
T156 ALNEDLKTWTAADMA
M162 KTWTAADMAAQITRR
K170 AAQITRRKWEQAGAA
Y183 AAERDRAYLEGECVE
W191 LEGECVEWLRRYLKN
N200 RRYLKNGNAtLLRTD
T202‑p YLKNGNAtLLRTDPP
K210 LLRTDPPKAHVTHHR
P219 HVTHHRRPEGDVTLR
K267 AGDGTFQKWASVVVP
S270 GTFQKWASVVVPLGK
L275 WASVVVPLGKEQKYT
K343 RRRNTGGKGGDyALA
- gap
- gap
Y347‑p TGGKGGDyALAPGsQ
S353‑p DyALAPGsQssDMsL
S355‑p ALAPGsQssDMsLPD
- gap
- gap
- gap
- gap
S356‑p LAPGsQssDMsLPDC
S359‑p GsQssDMsLPDCKV_
K364 DMsLPDCKV______
- gap
  HLAC iso25  
T17 LAVALAPTQTRAGPH
S25 QTRAGPHSLRYFYTT
Y48 PRFISVGYVDNTEFV
T52 SVGYVDNTEFVRFDS
Y80 MEQEGPEYWERETQK
K87 YWERETQKSKGQKES
K89 ERETQKSKGQKESFR
S94 KSKGQKESFRVDLRT
R142 LQYAYDGRDYIALNE
Y144 YAYDGRDYIALNEDL
T153 ALNEDLKTWTAADMA
M159 KTWTAADMAAQITRH
K167 AAQITRHKWEQAGAA
Y180 AAELYKAYLEGECVE
S188‑p LEGECVEsLRRYLEL
N197 RRYLELGNATLLRTD
T199 YLELGNATLLRTDSP
K207 LLRTDSPKAHVTHHS
P216 HVTHHSRPKDKVTLR
K264 AGDGTFQKWASVVVP
S267 GTFQKWASVVVPLGK
L272 WASVVVPLGKEQNYT
K338‑ub RRRNTGGkGGDyALA
- gap
- gap
Y342‑p TGGkGGDyALAPGsQ
S348‑p DyALAPGsQtsDLsL
T350‑p ALAPGsQtsDLsLPD
- gap
- gap
- gap
- gap
S351‑p LAPGsQtsDLsLPDC
S354‑p GsQtsDLsLPDCKA_
K359 DLsLPDCKA______
- gap
  HLAC iso26  
T20 LAAALAPTQTRAGPH
S28 QTRAGPHSMRYFETA
Y51 PRYISVGYVDNkEFV
K55‑ub SVGYVDNkEFVRFDS
Y83 MEQEGPEYWERITQI
I90 YWERITQIAKGQEQW
K92 ERITQIAKGQEQWFR
W97 IAKGQEQWFRVNLRT
C145 EQFAYDGCDYIALNE
Y147 FAYDGCDYIALNEDL
T156 ALNEDLKTWTAADMA
M162 KTWTAADMAAQITRR
K170‑ub AAQITRRkWEQAGAA
Y183 AAEYYRAYLEGECVE
W191 LEGECVEWLHRYLKN
N200 HRYLKNGNAtLLRTD
T202‑p YLKNGNAtLLRTDSP
K210 LLRTDSPKAHVTHHP
S219 HVTHHPRSKGEVTLR
K267 AGDGTFQKWASVVVP
S270 GTFQKWASVVVPLGK
L275 WASVVVPLGKEQNYT
K340‑ub RRRNTGGkGGDyALA
- gap
- gap
Y344‑p TGGkGGDyALAPGsQ
S350‑p DyALAPGsQssEMsL
S352‑p ALAPGsQssEMsLRD
- gap
- gap
- gap
- gap
S353‑p LAPGsQssEMsLRDC
S356‑p GsQssEMsLRDCKA_
K361 EMsLRDCKA______
- gap
  HLAC iso27  
T17 LAAALAPTQTRAGPH
S25 QTRAGPHSLRYFETA
Y48 PRYISVGYVDNTEFV
T52 SVGYVDNTEFVRFDS
Y80 MEQEGPEYWERETQR
R87 YWERETQRAKGQEQS
K89 ERETQRAKGQEQSFR
S94 RAKGQEQSFRVDLRT
R142 QQHAYDGRDYIALNE
Y144 HAYDGRDYIALNEDL
T153 ALNEDLKTWTAADMA
M159 KTWTAADMAALITKQ
K167 AALITKQKWEQAGAA
Y180 AAERLRAYLEGACVE
W188 LEGACVEWLRRYLER
N197 RRYLERGNATLLRTD
T199 YLERGNATLLRTDSP
K207 LLRTDSPKAHVTHHP
S216 HVTHHPRSEDYVTLR
K264 AGDGTFQKWAsVVVP
S267‑p GTFQKWAsVVVPRGK
R272 WAsVVVPRGKEQNYT
K338 RRRNTGGKGGDYTLA
- gap
- gap
Y342 TGGKGGDYTLAPGSQ
S348 DYTLAPGSQSSDMSL
S350 TLAPGSQSSDMSLPD
- gap
- gap
- gap
- gap
S351 LAPGSQSSDMSLPDC
S354 GSQSSDMSLPDCKVM
K359 DMSLPDCKVMVDDPH
S367 VMVDDPHSLA_____
  rat

► Hide Isoforms
 
- gap
S4 ____GSHSLRYFVTA
Y27 PRFMEVGYVDDTEFV
T31 EVGYVDDTEFVRYDS
Y59 MEREGREYWERETRI
I66 YWERETRIAKGNEQT
K68 ERETRIAKGNEQTFR
T73 IAKGNEQTFRENLRT
R121 EQFAYDGRDYIVLNE
Y123 FAYDGRDYIVLNEDL
T132 VLNEDLKTWTAADTA
T138 KTWTAADTAARITRN
K146 AARITRNKWDRAGVA
Y159 VAERHKAYLEGKCLE
S167 LEGKCLESLLRYLEL
K176 LRYLELGKETLLRSD
T178 YLELGKETLLRSDPP
K186 LLRSDPPKAHVTLHP
P195 HVTLHPRPEGDVTLR
K243 AGDGTFQKWASVVVP
S246 GTFQKWASVVVPLGK
L251 WASVVVPLGKEQNYT
K321 RRRNTGGKVGVyAPA
- gap
- gap
Y325‑p TGGKVGVyAPAPSRD
S334 PAPSRDSSESSDVSL
S336 PSRDSSESSDVSLSD
- gap
- gap
- gap
- gap
S337 SRDSSESSDVSLSDC
S340 SSESSDVSLSDCKA_
K345 DVSLSDCKA______
- gap
  HLAC iso1  
T20‑p LAAALAPtQTRAGSH
S28‑p QTRAGSHsMRYFDIA
Y51 PRFIIVGYVDDTEFV
T55 IVGYVDDTEFVRFDS
Y83 MEPEGPEYWEEQTRR
R90 YWEEQTRRAKEGEQT
K92 EEQTRRAKEGEQTFR
T97 RAKEGEQTFRVNLRT
R145 EQYAYDGRDYIALNE
Y147 YAYDGRDYIALNEDL
T156 ALNEDLKTWTAADFA
F162 KTWTAADFAARISRN
K170 AARISRNKWDQAGVA