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Protein Page:
PRICKLE1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PRICKLE1 Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. Defects in PRICKLE1 are the cause of progressive myoclonic epilepsy type 1B (EPM1B). EPM1B is an autosomal recessive disorder characterized by myoclonus that progresses in severity over time, tonic-clonic seizures and ataxia. Defects in PRICKLE1 may be a cause of susceptibility to neural tube defects (NTD). Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. Belongs to the prickle / espinas / testin family. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: cytosol; nuclear membrane; nucleus
Molecular Function: protein binding; transcription factor binding; zinc ion binding
Biological Process: negative regulation of transcription, DNA-dependent; neural tube closure; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein import into nucleus; Wnt receptor signaling pathway, planar cell polarity pathway
Disease: Epilepsy, Progressive Myoclonic 1b
Reference #:  Q96MT3 (UniProtKB)
Gene Symbols: PRICKLE1
Molecular weight: 94,300 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Select Structure to View Below

PRICKLE1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T21‑p FGCQRSStSDDDSGC
0 2 S315 LGEDVHASDSSDSAF
0 1 S317 EDVHASDSSDSAFQS
0 1 S353‑p CRQSLLLsPALNYKF
0 1 K359 LsPALNYKFPGLSGN
0 1 S379‑p SRKLDDLsLSRQGTS
0 1 K394 FASEEFWKGRVEQET
0 1 S445‑p RASEHWIsDNMVKsK
0 1 S451‑p IsDNMVKsKTELKQN
0 2 S476 SDMYWAQSQDGLGDS
0 1 S493‑p GSHPGPAssRRLQEL
0 1 S494‑p SHPGPAssRRLQELE
0 5 S591 NSSMLHRSAESLKsL
0 3 S594 MLHRSAESLKsLSSE
0 3 S597‑p RSAESLKsLSSELCP
0 5 S624 PVLRRSKSQSRPQQV
0 1 S653‑p EIRQPPMsERTRRRV
0 7 Y661 ERTRRRVYNFEERGs
0 1 S668‑p YNFEERGsRSHHHRR
0 3 S681‑p RRRRSRKsRsDNALN
0 9 S683‑p RRSRKsRsDNALNLV
0 1 T691‑p DNALNLVtERKYSPK
0 1 Y731 YIQNADLYGQYAHAT
  mouse

 
T21 FGCQRSSTSDDDSGC
S315‑p LGEDIHAsDsSDSAF
S317‑p EDIHAsDsSDSAFQS
S353‑p CRQSLLLsPALNYkF
K359‑ub LsPALNYkFPGLSGN
S379 SRKLDDVSLASRQGA
K395‑ub FANEEFWkARVEQEA
P446 RASEHWIPDNMVTNK
N452 IPDNMVTNKPEVKPN
S477‑p SDMYWAQsQDGLGDS
S494 GSHPGPASSRRLQEL
S495 SHPGPASSRRLQELD
S592‑p NSSMLHRsAEsLQsL
S595‑p MLHRsAEsLQsLNSG
S598‑p RsAEsLQsLNSGLCP
S625‑p PVLRRSKsQSRPQQV
S654‑p EIRQPPMsERTRRRA
Y662 ERTRRRAYHFEERGS
S669 YHFEERGSRPHHHRH
S682‑p RHRRSRKsRsDNALN
S684‑p RRSRKsRsDNALNLV
T692 DNALNLVTERKYSAK
Y732 YMQNANLYSQYAHAT
  rat

 
T21 FGCQRSSTSDDDSGC
S315 LGEDIHASDSSDSAF
S317 EDIHASDSSDSAFQS
S353 CRQSLLLSPALNYKF
K359 LSPALNYKFPGLSGS
S379 SRKLDDVSLSGQGAG
K394 FAHEEFWKARVDQEA
P445 RASEHWIPDNMVTNK
N451 IPDNMVTNKPEAKQN
S476‑p SDMYWAQsQDGLGDS
S493 GSHPGPASSRRLQEL
S494 SHPGPASSRRLQELD
S591 NSSMLHRSAESLKSL
S594 MLHRSAESLKSLNSE
S597 RSAESLKSLNSELCP
S624 PVLRRSKSQSRPQQV
S653 EIRQPPMSERTRRRV
Y661‑p ERTRRRVyHFEERGS
S668 yHFEERGSRPHHHRH
S681 RHRRSRKSRSDNALN
S683 RRSRKSRSDNALNLV
T691 DNALNLVTERKYSAK
Y731‑p YMQNANLyGQYAHTT
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