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Protein Page:
C/EBP-alpha (human)

C/EBP-alpha a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-beta and CEBP-gamma. Binds to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: nucleus
Molecular Function: DNA binding; kinase binding; protein binding; protein homodimerization activity; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: fat cell differentiation; generation of precursor metabolites and energy; glucose homeostasis; granulocyte differentiation; lipid homeostasis; liver development; lung development; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription, DNA-dependent; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase II promoter; transcription, DNA-dependent
Disease: Leukemia, Acute Myeloid
Reference #:  P49715 (UniProtKB)
Alt. Names/Synonyms: C/EBP alpha; C/EBP-alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha; CEBP; CEBPA
Gene Symbols: CEBPA
Molecular weight: 37,561 Da
Basal Isoelectric point: 7.27  Predict pI for various phosphorylation states
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