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Protein Page:
Bcl-2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Bcl-2 a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Autophagy; Apoptosis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q21.3
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nuclear membrane; nucleus; pore complex
Molecular Function: BH3 domain binding; channel activity; channel inhibitor activity; identical protein binding; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein phosphatase 2A binding; sequence-specific DNA binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: actin filament organization; apoptosis; axon regeneration; axonogenesis; B cell homeostasis; B cell lineage commitment; B cell proliferation; B cell receptor signaling pathway; behavioral fear response; CD8-positive, alpha-beta T cell lineage commitment; cell aging; cell growth; cellular response to glucose starvation; cochlear nucleus development; defense response to virus; digestive tract morphogenesis; DNA damage response, signal transduction resulting in induction of apoptosis; ear development; endoplasmic reticulum calcium ion homeostasis; female pregnancy; focal adhesion formation; gland morphogenesis; glomerulus development; hair follicle morphogenesis; homeostasis of number of cells within a tissue; humoral immune response; induction of apoptosis by oxidative stress; induction of apoptosis via death domain receptors; innate immune response; lymphoid progenitor cell differentiation; male gonad development; melanin metabolic process; melanocyte differentiation; mesenchymal cell development; metanephros development; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cellular pH reduction; negative regulation of mitochondrial depolarization; negative regulation of myeloid cell apoptosis; negative regulation of neuron apoptosis; negative regulation of ossification; negative regulation of osteoblast proliferation; negative regulation of retinal cell programmed cell death; neuron apoptosis; oocyte development; organ growth; ossification; ovarian follicle development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pigment granule organization and biogenesis; positive regulation of B cell proliferation; positive regulation of catalytic activity; positive regulation of cell growth; positive regulation of melanocyte differentiation; positive regulation of multicellular organism growth; positive regulation of neuron maturation; positive regulation of peptidyl-serine phosphorylation; positive regulation of skeletal muscle fiber development; positive regulation of smooth muscle cell migration; post-embryonic development; programmed cell death; protein amino acid dephosphorylation; protein polyubiquitination; regulation of calcium ion transport; regulation of cell-matrix adhesion; regulation of gene expression; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of nitrogen utilization; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; regulation of protein stability; regulation of transmembrane transporter activity; regulation of viral genome replication; release of cytochrome c from mitochondria; renal system process; response to cytokine stimulus; response to DNA damage stimulus; response to drug; response to gamma radiation; response to glucocorticoid stimulus; response to hydrogen peroxide; response to iron ion; response to nicotine; response to radiation; response to toxin; response to UV-B; spleen development; T cell differentiation in the thymus; T cell homeostasis; thymus development; transmembrane transport; ureteric bud branching
Reference #:  P10415 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl-2; BCL2
Gene Symbols: BCL2
Molecular weight: 26,266 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Autophagy Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcl-2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: T56‑p, T69‑p, S70‑p, T74‑p, S87‑p
apoptosis, induced: T56‑p, S70‑p, T74‑p, S87‑p
apoptosis, inhibited: T56‑p, T69‑p, S70‑p, T74‑p, S87‑p
cell cycle regulation: T56‑p
cell growth, altered: S70‑p
activity, inhibited: S70‑p, S87‑p
intracellular localization: S70‑p
molecular association, regulation: T56‑p, T69‑p, S70‑p, S87‑p
protein conformation: S87‑p
protein stabilization: T56‑p, T74‑p, S87‑p
ubiquitination: T56‑p, T74‑p, S87‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y9‑p AHAGRTGyDNREIVM
1 0 K22‑ub VMKYIHYkLSQRGYE
1 0 S24 KYIHYkLSQRGYEWD
11 0 T56‑p FSSQPGHtPHPAASR
8 0 T69‑p SRDPVARtsPLQtPA
37 1 S70‑p RDPVARtsPLQtPAA
4 0 T74‑p ARtsPLQtPAAPGAA
19 0 S87‑p AAAGPALsPVPPVVH
0 2 Y235‑p ACITLGAyLGHK___
2875 : Phospho-Bcl-2 (Thr56) Antibody (Human Specific)
2827 : Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb
2834 : Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  mouse

 
Y9 AQAGRTGYDNREIVM
K22 VMKYIHYKLSQRGYE
S24 KYIHYKLSQRGYEWD
N56 FSFQPESNPMPAVHR
T69‑p HRDMAARtsPLRPLV
S70‑p RDMAARtsPLRPLVA
P74 ARtsPLRPLVATAGP
S84‑p ATAGPALsPVPPVVH
Y232 ACITLGAYLGHK___
  rat

 
Y9 AQAGRTGYDNREIVM
K22 VMKYIHYKLsQRGYE
S24‑p KYIHYKLsQRGYEWD
N56 FSFQPESNRTPAVHR
T69 HRDTAARTsPLRPLV
S70‑p RDTAARTsPLRPLVA
P74 ARTsPLRPLVANAGP
S84‑p ANAGPALsPVPPVVH
Y232 ACITLGAYLGHK___
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