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Protein Page:
Bcl-2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Bcl-2 a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Oncoprotein; Autophagy; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q21.3
Cellular Component: cytoplasm; endoplasmic reticulum; membrane; mitochondrial outer membrane; mitochondrion; nuclear membrane; nucleus; pore complex
Molecular Function: BH3 domain binding; channel activity; channel inhibitor activity; identical protein binding; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; ubiquitin protein ligase binding
Biological Process: apoptosis; B cell proliferation; B cell receptor signaling pathway; defense response to virus; DNA damage response, signal transduction resulting in induction of apoptosis; endoplasmic reticulum calcium ion homeostasis; humoral immune response; induction of apoptosis via death domain receptors; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of cellular pH reduction; negative regulation of mitochondrial depolarization; negative regulation of neuron apoptosis; neuron apoptosis; positive regulation of B cell proliferation; positive regulation of cell growth; protein polyubiquitination; regulation of calcium ion transport; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; regulation of transmembrane transporter activity; release of cytochrome c from mitochondria; response to cytokine stimulus; response to DNA damage stimulus; response to drug; response to iron ion; response to nicotine; response to toxin
Reference #:  P10415 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl-2; BCL2
Gene Symbols: BCL2
Molecular weight: 26,266 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Autophagy Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcl-2

Protein Structure Not Found.
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Sites Implicated In
apoptosis, altered: T56‑p, T69‑p, S70‑p, T74‑p, S87‑p
apoptosis, induced: T56‑p, S70‑p, T74‑p, S87‑p
apoptosis, inhibited: T56‑p, T69‑p, S70‑p, T74‑p, S87‑p
cell cycle regulation: T56‑p
cell growth, altered: S70‑p
activity, inhibited: S70‑p, S87‑p
intracellular localization: S70‑p
molecular association, regulation: T56‑p, T69‑p, S70‑p, S87‑p
protein conformation: S87‑p
protein stabilization: T56‑p, T74‑p, S87‑p
ubiquitination: T56‑p, T74‑p, S87‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y9‑p AHAGRTGyDNREIVM
1 0 K22‑ub VMKYIHYkLSQRGYE
1 0 S24 KYIHYkLSQRGYEWD
11 0 T56‑p FSSQPGHtPHPAASR
8 0 T69‑p SRDPVARtsPLQtPA
37 1 S70‑p RDPVARtsPLQtPAA
4 0 T74‑p ARtsPLQtPAAPGAA
19 0 S87‑p AAAGPALsPVPPVVH
0 1 Y235‑p ACITLGAyLGHK___
2875 : Phospho-Bcl-2 (Thr56) Antibody (Human Specific)
2827 : Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb
2834 : Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  mouse

 
Y9 AQAGRTGYDNREIVM
K22 VMKYIHYKLSQRGYE
S24 KYIHYKLSQRGYEWD
N56 FSFQPESNPMPAVHR
T69‑p HRDMAARtsPLRPLV
S70‑p RDMAARtsPLRPLVA
P74 ARtsPLRPLVATAGP
S84‑p ATAGPALsPVPPVVH
Y232 ACITLGAYLGHK___
  rat

 
Y9 AQAGRTGYDNREIVM
K22 VMKYIHYKLsQRGYE
S24‑p KYIHYKLsQRGYEWD
N56 FSFQPESNRTPAVHR
T69 HRDTAARTsPLRPLV
S70‑p RDTAARTsPLRPLVA
P74 ARTsPLRPLVANAGP
S84‑p ANAGPALsPVPPVVH
Y232 ACITLGAYLGHK___
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