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Protein Page:
HMGCS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HMGCS1 This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10
Chromosomal Location of Human Ortholog: 5p14-p13
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function: hydroxymethylglutaryl-CoA synthase activity
Biological Process: cholesterol biosynthetic process
Reference #:  Q01581 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMCS1; HMG-CoA synthase; HMGCS; HMGCS1; Hydroxymethylglutaryl-CoA synthase, cytoplasmic; MGC90332
Gene Symbols: HMGCS1
Molecular weight: 57,294 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HMGCS1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 12 S4‑p ____MPGsLPLNAEA
0 3 K46‑ac YDGVDAGkYTIGLGQ
0 3 K46‑ub YDGVDAGkYTIGLGQ
0 2 K100 GTETIIDKSKSVKTN
0 2 K100‑ub GTETIIDkSKSVKTN
0 1 Y205 MQHAYDFYkPDMLSE
0 6 K206‑ac QHAYDFYkPDMLSEy
0 2 K206‑ub QHAYDFYkPDMLSEy
0 2 S211 FYkPDMLSEyPIVDG
0 7 Y213‑p kPDMLSEyPIVDGKL
0 1 S221‑p PIVDGKLsIQCYLsA
0 1 S227‑p LsIQCYLsALDRCYS
0 1 K246‑ac KIHAQWQkEGNDKDF
0 1 K246‑ub KIHAQWQkEGNDKDF
0 1 K273‑ac PYCKLVQkSLARMLL
0 3 K273‑ub PYCKLVQkSLARMLL
0 7 K291‑ub LNDQNRDkNSIYsGL
0 1 S296‑p RDkNSIYsGLEAFGD
0 1 Y310‑p DVKLEDTyFDRDVEk
0 2 K317‑ac yFDRDVEkAFMkASS
0 4 K317‑ub yFDRDVEkAFMkASS
0 1 K321‑ac DVEkAFMkASSELFS
0 5 K321‑ub DVEkAFMkASSELFS
0 6 K330‑ub SSELFSQkTKASLLV
0 2 S361‑p ASVLAQYsPQQLAGk
0 1 K368‑ub sPQQLAGkRIGVFSY
0 4 K400‑ub TPGSALDkITASLCD
0 20 K409‑ac TASLCDLkSRLDSRT
0 3 K409‑ub TASLCDLkSRLDSRT
0 1 K409‑sc TASLCDLkSRLDSRT
0 4 K428‑ub DVFAENMkLREDTHH
0 5 T471‑p RTYARRPtPNDDtLD
0 7 T476‑p RPtPNDDtLDEGVGL
0 3 S486‑p EGVGLVHsNIATEHI
1 46 S495‑p IATEHIPsPAkkVPR
0 2 K498‑ub EHIPsPAkkVPRLPA
0 1 K499‑ub HIPsPAkkVPRLPAT
0 14 S516‑p EPEAAVIsNGEH___
  mouse

 
S4 ____MPGSLPLNAEA
K46‑ac YDGVDAGkYTIGLGQ
K46‑ub YDGVDAGkYTIGLGQ
K100‑ac GTETIIDkSKSVKSN
K100‑ub GTETIIDkSKSVKSN
Y205‑p MQHAYDFykPDMLsE
K206‑ac QHAYDFykPDMLsEY
K206‑ub QHAYDFykPDMLsEY
S211‑p FykPDMLsEYPVVDG
Y213 kPDMLsEYPVVDGKL
S221 PVVDGKLSIQCYLSA
S227 LSIQCYLSALDRCYS
K246 KIRAQWQKEGKDKDF
K246 KIRAQWQKEGKDKDF
K273 PYCKLVQKSLARMFL
K273‑ub PYCKLVQkSLARMFL
K291‑ub LNDQNRDkNSIYSGL
S296 RDkNSIYSGLEAFGD
Y310 DVKLEDTYFDRDVEk
K317‑ac YFDRDVEkAFMkASS
K317‑ub YFDRDVEkAFMkASS
K321 DVEkAFMKASSELFN
K321‑ub DVEkAFMkASSELFN
K330‑ub SSELFNQkTKASLLV
S361 ASVLAQYSPQQLAGK
K368 SPQQLAGKRVGVFSY
K400‑ub TPGSALDkITASLCD
K409‑ac TASLCDLkSRLDSRT
K409‑ub TASLCDLkSRLDSRT
K409 TASLCDLKSRLDSRT
K428‑ub DVFAENMkLREDTHH
F471 RTYARRPFTNDHSLD
S476 RPFTNDHSLDEGMGL
S486‑p EGMGLVHsNTATEHI
S495‑p TATEHIPsPAkKVPR
K498‑ub EHIPsPAkKVPRLPA
K499 HIPsPAkKVPRLPAT
S516‑p ESESAVIsNGEH___
  rat

 
S4 ____MPGSLPLNAEA
K46‑ac YDGVDAGkYTIGLGQ
K46 YDGVDAGKYTIGLGQ
K100‑ac GTETIIDkSKSVKSN
K100 GTETIIDKSKSVKSN
Y205 MQHAYDFYkPDMLSE
K206‑ac QHAYDFYkPDMLSEY
K206 QHAYDFYKPDMLSEY
S211 FYkPDMLSEYPVVDG
Y213 kPDMLSEYPVVDGKL
S221 PVVDGKLSIQCYLSA
S227 LSIQCYLSALDRCYS
K246 KIRAQWQKEGKDKDF
K246 KIRAQWQKEGKDKDF
K273 PYCKLVQKSLARMFL
K273 PYCKLVQKSLARMFL
K291 LNDQNRDKNSIYSGL
S296 RDKNSIYSGLEAFGD
Y310 DVKLEDTYFDRDVEK
K317 YFDRDVEKAFMKASA
K317 YFDRDVEKAFMKASA
K321 DVEKAFMKASAELFN
K321 DVEKAFMKASAELFN
K330 SAELFNQKTKASLLV
S361 ASVLAQYSPQQLAGK
K368 SPQQLAGKRIGVFSY
K400 TPGSALDKITASLCD
K409 TASLCDLKSRLDSRT
K409 TASLCDLKSRLDSRT
K409 TASLCDLKSRLDSRT
K428 DVFAENMKLREDTHH
S471‑p RTYARRPsTNDHSLD
S476 RPsTNDHSLDEGVGL
S486 EGVGLVHSNTATEHI
S495‑p TATEHIPsPAKKVPR
K498 EHIPsPAKKVPRLPA
K499 HIPsPAKKVPRLPAT
S516‑p EPESAVIsNGEH___
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