|
HBEGF
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. Note: This description may include information from UniProtKB.
|
| Protein type: Cell surface; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 5q31.3 |
|
Cellular Component: cell surface; extracellular region; extracellular space; integral to plasma membrane; plasma membrane
|
|
Molecular Function: epidermal growth factor receptor binding; growth factor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
|
|
Biological Process: epidermal growth factor receptor signaling pathway; MAPKKK cascade; muscle development; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; regulation of phosphoinositide 3-kinase cascade; signal transduction
|
|
Reference #:
Q99075
(UniProtKB)
|
|
Alt. Names/Synonyms: Diphtheria toxin receptor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); DT-R; DTR; DTS; DTSF; HB-EGF; HBEGF; HEGFL; Heparin-binding EGF-like growth factor; heparin-binding epidermal growth factor; Proheparin-binding EGF-like growth factor
|
|
Gene Symbols: HBEGF
|
|
Molecular weight:
23,067 Da
|
|
Basal Isoelectric point:
9.47
Predict pI for various phosphorylation states
|
|
CST Pathways:
ErbB/HER Signaling
|
